Chronic systemic inflammation is essential in many chronic non-infectious diseases, including type 2 diabetes, obesity and metabolic syndrome (MS). This study aimed at characterization of inflammatory reaction as a component diet-induced MS rat model. Thirty-three male Wistar rats were distributed into two groups designated 'control' (n = 15) 'experimental (MS)' 18). The fed, respectively, regu...

C-reactive protein (CRP) is routinely assessed as a marker of systemic inflammation in rheumatoid arthritis (RA). However, it also an immune regulator that plays important role inflammatory pathways associated with RA and promotes atherogenic effects. Comorbidities linked to are common RA, CRP has been the risk for cardiovascular disease, diabetes, metabolic syndrome, pulmonary diseases, depres...

The SARS-CoV-2 virus epidemic and pandemic is the greatest challenge for humanity at beginning of 21st century. Although, after 1984, civilization experienced this epidemiological phenomenon through HIV AIDS, atypical pneumonia, swine flu, bird SARS-CoV-1, infections give way century to chronic, non-infectious diseases. COVID-19 disease a systemic affecting whole body all its organs functions c...

Obesity and insulin resistance are hallmarks of the metabolic syndrome, which is associated with low-grade chronic inflammation. Clusterin/apolipoprotein J is an abundant plasma chaperone protein that has recently been suggested as a potential biomarker that reflects the inflammatory process in Alzheimer's disease. In the present study, we investigated anthropometric and clinical factors affect...

Sjogren's Syndrome is a chronic systemic autoimmune disorder that usually accompanied by dry eyes and mouth due to inflammation abnormalities in the lacrimal salivary glands. This disease can cause decrease production of secretions other organs need moisture, such as nose, throat, respiratory tract, skin. The prevalence general population not yet known, but Americas 0.05-4.8% population. Sixty ...

Introduction CINCA syndrome, also known as NOMID, is a rare autoinflammatory disease caused by the NLRP3 mutations. It has been known that conventional genetic analysis failed to detect disease-causing mutations in approximately 40% of patients. We have recently identified NLRP3 somatic mosaicism on 70% of these ”mutation-negative” patients in the international collaborative study (Tanaka N. an...

auto-inflammatory syndromes are a new group of distinct hereditable disorders characterized by episodes of seemingly unprovoked inflammation (most commonly in skin, joints, gut, and eye), the absence of a high titer of auto-antibodies or auto-reactive t cells, and an inborn error of innate immunity. a narrative literature review was carried out of studies related to auto-inflammatory syndromes ...

Neuro-inflammation, biochemical and cellular responses of the nervous system to injury, infection or neurodegenerative diseases, is a major risk factor for Alzheimer's, Parkinson's and Multiple Sclerosis. Periodontitis is a serious bacterial gum infection that damages the soft tissue and teeth supporting bones, causing teeth loss. It also renders systemic inflammation by secretion of pro-inflam...