Pancreatobiliary malignancies are relatively uncommon and the overall prognosis is poor. Treatment options for advanced disease are limited to systemic therapy for metastatic disease and a combination of systemic therapy and radiation therapy for locally advanced but unresectable tumors. There have been significant advances in the treatment of pancreatobiliary cancers in recent years but the pr...

INTRODUCTION Rheumatic diseases (RDs) are associated with different cancers; however, it is unclear whether particular cancers are more prevalent in certain RDs. In the present study, we examined the relative incidence of several cancers in a single homogeneous cohort of patients with different RDs. METHODS Patients (N = 3,586) diagnosed with rheumatoid arthritis (RA), systemic lupus erythema...

OBJECTIVE To measure the incidence of cancer in patients with psoriasis, stratified by the severity of their disease. DESIGN A cohort study. SETTING Administrative claims records obtained from Medicaid programs in 3 US states. PARTICIPANTS All individuals in the claims database who qualified for 1 of the 5 following groups: severe psoriasis as defined by treatment with systemic medication...

BACKGROUND Laparoscope-assisted gastrectomy in treating patients with gastric cancers developed with a background of highly invasive traditional surgery and is being increasingly performed in the Asian Pacific area. This study systemically investigated the technique and clinical results for comparison with traditional radical subtotal gastrectomy for gastric cancers. METHODS Clinical studies ...

Head and neck cancers, most of which are squamous cell tumours, have an unsatisfactory prognosis despite intensive local treatment. This can be attributed, among other factors, to tumour recurrences inside or outside the treated area, and metastases at more distal locations. These tumours therefore require not only the standard surgical and radiation treatments, but also effective systemic trea...

Plasmacytoid dendritic cells (pDCs), also called natural interferon (IFN)-producing cells, represent a specialized cell type within the innate immune system. pDCs are specialized in sensing viral RNA and DNA by toll-like receptor-7 and -9 and have the ability to rapidly produce massive amounts of type 1 IFNs upon viral encounter. After producing type 1 IFNs, pDCs differentiate into professional...

Randomized controlled mammography screening trials and the evaluation of service screening have unequivocally proven that regular mammography screening significantly reduces mortality from breast cancer. This evidence contradicts the theory of Fisher, claiming that breast cancer is a systemic disease from its inception and undermines the justification for systemic therapy in most screen-detecte...

background non-melanoma skin cancers (nmsc) are the most common cancers worldwide. these cancers are not accompanied by high mortality however they lead to various complications. evaluation of nmsc predisposing factors could result in preventive measures, improvement of quality of life and reduction of medical costs. objectives this study aimed to determine predisposing factors of non-melanoma ...

background: the induction of cancer appears to be the most important effect of low-dose ionizing radiation to occur in an exposed population. in developing countries 94% of human radiation is from natural sources. in iran some high altitude regions such as, chaharmahal & bakhtiari has high levels of the natural background radiation (higher than the worldwide average). therefore, investigation o...

introduction: c - reactive protein (crp) is an acute-phase plasma protein that can be used as a marker of activation of the immune system. in response to several inflammatory reactions,the concentration of crp increases and recently have been applicated as a cancer detector in some studies. we aimed to evaluate the relation between crp level and the staging and grading of gastric and colon mali...