In order to analyze the effect of OC kappa in redox status, photosynthesis, basal metabolism and growth in Eucalyptus globulus, trees were treated with water (control), with OC kappa at 1 mg mL(-1), or treated with inhibitors of NAD(P)H, ascorbate (ASC), and glutathione (GSH) syntheses and thioredoxin reductase (TRR) activity, CHS-828, lycorine, buthionine sulfoximine (BSO), and auranofin, resp...

For many years, the main application of [(18)F]F-DOPA has been the PET imaging of neuropsychiatric diseases, movement disorders, and brain malignancies. Recent findings however point to very favorable results of this tracer for the imaging of other malignant diseases such as neuroendocrine tumors, pheochromocytoma, and pancreatic adenocarcinoma expanding its application spectrum. With the appli...

Sulfuric acid {[3-(3-silicapropyl)sulfanyl]propyl}ester (SASPSPE) is employed as a recyclable catalyst for the synthesis of α-amino nitriles. These syntheses were performed via a one-pot three-component condensation of aldehydes, amines, and trimethylsilyl cyanide under mild reaction conditions at room temperature. The catalyst could be recycled and reused several times without any loss of effi...

The syntheses of dextrans (l-5) and levans (6-10) from sucrose by enzymes from certain bacteria and the syntheses of glycogens and starches from glucose-l-phosphate by phosphorylases from yeast (11) and animal (12-15) and plant (16, 17) tissues have a fundamental point of similarity in that, with all of them, the substrate contains the basic unit of the final polymer product in the form of a gl...

Sphingosines are a related class of long chain aliphatic compounds possessing a 2-amino-l,3-diol moiety. The most common member of this group found in nature is ( 2 S , 3 R ) D e r y t h r o 2 a m i n o l , 3 o c t a d e c 4 E e n e diol l a and is frequently referred to as sphingosine. These molecules are the backbone of more complex sphingolipids, including ceramide, sphingomyelin, cerebrosid...

The development of operationally straightforward and cost-effective routes for the assembly of heterocycles from simple inputs is important for many scientific endeavors, including pharmaceutical, agrochemical, and materials research. In this article we describe the development of a new air-stable cationic Co(III) catalyst for convergent, one-step benchtop syntheses of N-aryl-2H-indazoles and f...

reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. substituted-2-(l-methyl-5-nitro-2-imidazo1yl)-4.- methyl-(or phenyl-) quinolines (14) were prepared through the reaction of 2- acetyl-5-nitro-1-methyl-imi...

A concise and scalable synthesis of a cis-fused bicyclo[5.3.0]decane ring system has been developed for the total synthesis of echinopines. The core of the natural products was constructed efficiently through an intramolecular 1,3-dipolar cycloaddition and ring contraction strategy.

In the preceding papers1'2), we reported the syntheses and biological properties of carbapenem compounds having a

The Canadian Institute of Health Research (CIHR) defines knowledge translation as 'a dynamic and iterative process that includes the synthesis, dissemination, exchange and ethically-sound application of knowledge to improve the health of Canadians, provide more effective health services and products and strengthen the healthcare system'. This definition highlights the importance of knowledge sy...