Aim: This study aimed to investigate the effects of relaxin (RLX) on hypertensive disorders pregnancy (HDP) and fetal growth restriction (FGR) using a nitric oxide synthase (NOS) inhibitor-induced HDP murine model.

Abstract Background The oxidative phosphorylation (OXPHOS) that takes place in the mitochondria produces chemical energy form of ATP, main source heart. Proper mitochondrial function determines contractility Changes myocardial ATP levels are often associated with cardiovascular disease. However, dysfunction remains an unmet therapeutic challenge. F1FO ATP-synthase protein complex catalyses last...

Lumazine synthase and riboflavin synthase catalyze the last two steps in the biosynthesis of riboflavin. To obtain structural and mechanistic probes of these two enzymes, as well as inhibitors of potential value as antibiotics, a sulfur analogue of the pyrimidine substrate of the lumazine synthase-catalyzed reaction and product of the riboflavin synthase-catalyzed reaction was designed. Facile ...

Correction for ‘Engineering strategies rational polyketide synthase design’ by Maja Klaus et al., Nat. Prod. Rep., 2018, 35, 1070–1081, DOI: 10.1039/C8NP00030A.

objective(s): nucleus raphe magnus (nrm) that is involved in the regulation of body temperature contains nitric oxide (no) synthase. considering the effect of no on skin blood flow control, in this study, we assessed its thermoregulatory role within the raphe magnus. materials and methods: to this end, tail blood flow of male wistar rats was measured by laser doppler following the induction of ...

CDP-diacylglycerol (CDP-DG) is an important branchpoint intermediate in eucaryotic phospholipid biosynthesis and could be a key regulatory site in phospholipid metabolism. Therefore, we examined the effects of growth phase, phospholipid precursors, and the disruption of phosphatidylcholine (PC) synthesis on the membrane-associated phospholipid biosynthetic enzymes CDP-DG synthase, phosphatidylg...