The aim of this research was to determine whether all memory T cells have the same propensity to migrate to the joint in patients with juvenile idiopathic arthritis. Paired synovial fluid and peripheral blood mononuclear cell proliferative responses to a panel of antigens were measured and the results correlated with a detailed set of laboratory and clinical data from 39 patients with juvenile ...

sarcomas are rare tumors account for about 1% of cancers in adult. soft tissue sarcomas are the most common one. synovial sarcoma's incident is about 10% of all sarcomas and most commonly rise from para-articular regions in young adults. based on our knowledge there have been only two reports of thyroid synovial sarcoma in medical literature. we report a 44-year old woman presented with a rapid...

OBJECTIVES The significance of the mast cell in the pathogenesis of rheumatic diseases has become more evident. Although mast cell hyperplasia is a feature of rheumatoid arthritis, the nature of mast cell chemoattractants involved in the recruitment of mast cells in joint diseases has not been studied in any detail. In this study the presence of mast cell chemotactic activity in synovial fluids...

Synovial tissue in rheumatoid arthritis is characterized by infiltration with large numbers of T lymphocytes and APCs as well as hyperplasia of synovial fibroblasts. Current understanding of the pathogenesis of RA includes the concept that synovial fibroblasts, which are essential to cartilage and bone destruction, are regulated by cytokines derived primarily from monocyte-macrophage cells. Rec...

INTRODUCTION Hypoxia is a microenvironmental feature in the inflamed joint, which promotes survival advantage for cells. The aim of this study was to examine the relationship of partial oxygen pressure in the synovial tissue (tPO(2)) in patients with inflammatory arthritis with macroscopic/microscopic inflammation and local levels of proinflammatory mediators. METHODS Patients with inflammato...

In the present investigation we have studied changes in the synovial fluid obtained from inflammatory and non-inflammatory joints, not only of lysosomal enzymes, but of five intracellular enzymes selected to represent different intracellular compartments. Although the study has not revealed a characteristic composition of the synovial fluid for any of the diseases studied, it has indicated that...

INTRODUCTION: The purpose of this study was the evaluation of synovial effusion (SE), synovial fluid (SF) and synovial tissue (ST) biomarkers in relation to disease activity indexes to assess the response to intraarticular (IA) tumor necrosis factor (TNF)-alpha blockers in psoriatic arthritis (PsA). METHODS: Systemic and local disease activity indexes (disease activity score (DAS); the Ritchie ...

Synovial biomarker analysis in rheumatoid arthritis can be used to evaluate drug effect in clinical trials of novel therapeutic agents. Previous studies of synovial gene expression for these studies have mainly relied on histological methods including immunohistochemistry and in situ hybridization. To increase the reliability of mRNA measurements on small synovial tissue samples, we developed a...

Rheumatoid arthritis results from a T cell-driven inflammation in the synovial membrane that is frequently associated with the formation of tertiary lymphoid structures. The significance of this extranodal lymphoid neogenesis is unknown. Microdissection was used to isolate CD4 T cells residing in synovial tissue T cell/B cell follicles. CD4 T cells with identical TCR sequences were represented ...

Synovial sarcoma develops as a primary neoplasm of soft tissues, particularly of the extremities, but it has been also reported in a large variety of sites. This tumor is not derived from “synovium”, but from immature mesenchymal elements. Synovial sarcoma accounts for approximately 8-14% of soft tissue sarcomas (1, 2). Although metastases to the lung and/or pleural cavity are common events in ...