Objective(s):We investigated the influence of genetic variation of the transforming growth-factor alpha (TGFA) locus on the relationship between smoking and oral clefts. Materials and methods:In this study 105 Iranian infants with non-syndromic cleft lip/palate and 218 controls with non-cleft birth defects were examined to test for associations among maternal exposures, genetic markers, and ora...

Objectives: To identify the various otological challenges associated with non-syndromic orofacial clefts, how these problems affect quality of life patients clefts and find out perspectives current trends in management problems. Design: We conducted systematic searches for retrospective studies, cross-sectional case-control cohorts’ longitudinal studies prospective controlled trials Medline Goo...

Cleft palate is a common birth defect in humans and is a common phenotype associated with syndromic mutations in fibroblast growth factor receptor 2 (Fgfr2). Cleft palate occurred in nearly all mice homozygous for the Crouzon syndrome mutation C342Y in the mesenchymal splice form of Fgfr2. Mutant embryos showed delayed palate elevation, stage-specific biphasic changes in palate mesenchymal prol...

Cleft lip and palate is the one of the most common visible congenital deformities. Approximately 30% of oral clefts are syndromic and are associated with some anomalies. Global surveys have shown that the frequency of cleft lip and palate varies greatly from country to country. The present study analysed demographic and associated anomalies in children attending the high volume Smile Train cent...

Address for Correspondence: Dr. Subhra Mandal, M.B.B.S. , M.D. (Anatomy), Associate Professor, Dept. of Anatomy, Medical College Kolkata, West Bengal, India. Mobile. No: +919477458100 E-Mail: [email protected] *1 Associate Professor, Dept. of Anatomy, Medical College Kolkata, West Bengal, India. 2 Post Graduate Resident in DNB ( PMR), S.N.P. Hospital, Kolkata, West Bengal, India. 3 Additi...

This retrospective study was carried out on consecutively collected dental casts, x-rays, and photos of 129 Swedish children who had been born with non-syndromic unilateral (U) cleft lip (CL), cleft lip and alveolus (CLA), or cleft lip and palate (CLP). The following dental characteristics were investigated in the primary and permanent dentitions: 1. the presence, eruption, position, and shape ...

UNLABELLED Cleft lip and/or palate (CL/P) represent the most common congenital anomalies of the face, corresponding to approximately 65% of all malformations of the craniofacial region. AIM to describe unusual clinical cases of non-syndromic CL/P (CL/PNS), diagnosed in a reference service in Minas Gerais, Brazil, and correlate these alterations with possible risk factors. MATERIALS AND METH...

BACKGROUND Cleft defects are one of the most frequent birth-deformities of the orofacial region and they are commonly associated with anomalies of the tooth structure, size, shape, formation, eruption, and tooth number. The aim of our study was to evaluate the prevalence, distribution, and potential association of combined hypodontia in cleft-affected patients with regard to all types of teeth ...

Background Tooth abnormalities are most often present in individuals with oral clefts than general population, and lead to a long-term impact on facial anatomy and self-esteem. The purpose of this study was to compare the proportion of dental anomalies between the cleft side and non-cleft side in individuals with non-syndromic unilateral alveolar clefts (AC). Material and Methods Twenty cone ...

The aim of this study was to assess hypoplasia in permanent maxillary anterior dentition. The sample for this study consisted of 60 subjects divided into two groups: Group 1 consisted of 30 subjects with complete unilateral cleft lip and palate. Group 2 consisted of 30 subjects with complete bilateral cleft lip and palate (both males and females). Informed consent was taken from all patients. I...