OBJECTIVES Stress sweating can occur in everyday situations independently of thermally-induced perspiration. It is triggered by emotionally challenging situations and leads to underarm wetness and a characteristic unpleasant malodor. In this study, we aimed to determine the long-term efficacy of three unperfumed antiperspirant (AP) formulas for different application forms (roll-on, stick, aeros...

The early description of cystic fibrosis (CF) dates back to late 30s. In 1936, Fanconi identified the association between the “congenital CF of the pancreas and broncheactasis" shortly followed by Andersen who in 1938 gave the complete anatomopathologic description of CF. In 1953, Di Sant'Agnese described an excess of sodium chloride in the sweat of children affected by CF. This discovery short...

This study assessed fluid balance, sodium losses, and effort intensity during indoor tennis match play (17 ± 2 °C, 42% ± 9% relative humidity) over a mean match duration of 68.1 ± 12.8 min in 16 male tennis players. Ad libitum fluid intake was recorded throughout the match. Sweat loss from change in nude body mass; sweat electrolyte content from patches applied to the forearm, calf, and thigh, ...

BACKGROUND The phenotypic spectrum of cystic fibrosis (CF) has expanded to include patients affected by single-organ diseases. Extensive genotyping and nasal potential difference (NPD) testing have been proposed to assist in the diagnosis of CF when sweat testing is inconclusive. However, the diagnostic yield of extensive genotyping and NPD and the concordance between NPD and the sweat test hav...

Sessile cultures of the skin bacteria Staphylococcus saprophyticus and Corynebacterium xerosis were grown using novel fine-celled foam substrata to test the outcome of challenge by methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa under three growth medium regimens (simulated sweat, simulated serum or simulated sweat substituted with simulated serum during the microbial chal...

The early description of cystic fibrosis (CF) dates back to late 30s. In 1936, Fanconi identified the association between the “congenital CF of the pancreas and broncheactasis" shortly followed by Andersen who in 1938 gave the complete anatomopathologic description of CF. In 1953, Di Sant'Agnese described an excess of sodium chloride in the sweat of children affected by CF. This discovery short...

BACKGROUND Patients with familial dysautonomia (FD) manifest episodic hyperhidrosis despite the reduction of sudomotor fibres and sweat glands associated with this autonomic neuropathy. We assessed peripheral sudomotor nerve fibre and sweat gland function to determine if this symptom was due to peripheral denervation hypersensitivity. METHODS In 14 FD patients and 11 healthy controls, direct ...

C sric FIBROSIS of the pancreas is now acknowledged to be one of the most serious chronic diseases of childhood, with an estimated incidence in its fully manifested form of 1-1.7 per 1000 live births (1). Chances for early diagnosis and treatment-essential before the pulmonary disease that dominates the clinical picture has caused irreversible changes-were greatly enhanced with the introduction...

In isolated sweat glands, bumetanide inhibits sweat secretion. The mRNA encoding bumetanide-sensitive Na(+)-K(+)-Cl(-) cotransporter (NKCC) isoform 1 (NKCC1) has been detected in sweat glands; however, the cellular and subcellular protein localization is unknown. Na(+)/H(+) exchanger (NHE) isoform 1 (NHE1) protein has been localized to both the duct and secretory coil of human sweat duct; howev...

SIR, We explored whether a simple unassisted transdermal delivery of botulinum toxin type A (BTX) is effective for treating palmar hyperhidrosis. Palmar hyperhidrosis is common and troublesome. Nonsurgical treatments include topical antiperspirants, iontophoresis, anticholinergic drugs and botulinum toxin injections. Most antiperspirants contain 1–2% aluminium salts and, although convenient and...