Cerebral venous oxygen saturation (SvO2) is an important biomarker of brain function. In this study, we aimed to explore the relative changes of regional cerebral SvO2 among axonal injury (AI) patients, non-AI patients and healthy controls (HCs) using quantitative susceptibility mapping (QSM). 48 patients and 32 HCs were enrolled. The patients were divided into two groups depending on the imagi...

DO2 = CaO2 × cardiac output where CaO2 is total oxygen content, made up largely of oxygen bound to haemoglobin and, to a much smaller degree, oxygen dissolved in plasma. DO2 therefore depends not only on the degree of oxygenation of the blood but also on cardiovascular function and haemoglobin concentration. Despite its importance, it is not the most tightly regulated physiological parameter fo...

Critically ill patients are threatened or affected by multi-organ failure (MOF). Tissue hypoxia is one of the most important co-factors of MOF. Venous oximetry allows the critical estimation of the global oxygen (O2) supply-demand ratio and can be gained from mixed (SvO2) and central venous blood (ScvO2). Cellular requirements dominate the feedback hierarchy of the O2-metabolism. This review de...

Signal quantitation in most near infrared spectroscopy (NIRS) instruments is achieved through solving simultaneous equations or multiple regression analysis. The aim of this study was to compare NIRS signal quantitation by conventional multiple regression to artificial neural networks. Sixteen adult sheep were used in the study of the effects of changes in cerebral blood flow and metabolism thr...

Background/Purpose: The cerebral metabolic rate of oxygen consumption (CMRO2) is a fundamental physiologic parameter that has only recently become amenable to measurement by noninvasive imaging modalities (1). Here, we present an approach based on simultaneous quantification of venous oxygen saturation (SvO2) and total flow, yielding CMRO2 in absolute physiologic units by invoking Fick’s equati...

PURPOSE To investigate how blood lactate concentration changes in the early postoperative course after the Fontan procedure, and whether such a change is associated with postoperative hemodynamics. MATERIALS AND METHODS Eight pediatric patients who underwent the Fontan procedure for congenital heart disease were included. Enrollment criteria were body weight >10 kg and staged Fontan procedure...

PurposeIntra-aortic balloon pump (IABP) therapy is often used to bridge patients durable left ventricular assist device (LVAD). We examined the hemodynamic changes following IABP insertion in cardiogenic shock requiring LVAD therapy.MethodsWe performed a retrospective observational study of receiving an as from 2015-2021. Hemodynamic metrics including right atrial pressure (RAP), pulmonary arte...