نتایج جستجو برای: survivin antisense

تعداد نتایج: 19309  

Journal: :middle east journal of cancer 0
bahareh owrangi shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran mojtaba habibagahi department of immunology, school of medicine, shiraz university of medical sciences, shiraz, iran ahmad hosseini shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran negin fazelzadeh haghighi department of immunology, school of medicine, shiraz university of medical sciences, shiraz, iran mohsen mardani department of immunology, school of medicine, shiraz university of medical sciences, shiraz, iran abdolrasoul talei department of surgery, school of medicine, shiraz university of medical sciences, shiraz, iran

background : mdm2, e-cadherin, survivin and her2 genes are involved in the regulation of normal cell growth. however, any crucial change in their expression levels can convert a normal cell into a cancer cell. numerous studies have identified alterations of these gene expression levels in various cancers, particularly in breast cancer. thus, they may be used as diagnostic biomarkers. in this ex...

2014
Sze Ue Iris Luk Hui Xue Hongwei Cheng Dong Lin Peter W. Gout Ladan Fazli Colin C. Collins Martin E. Gleave Yuzhuo Wang

Treatment resistance, the major challenge in the management of advanced prostate cancer, is in part based on resistance to apoptosis. The Inhibitor of Apoptosis (IAP) family is thought to play key roles in survival and drug resistance of cancer via inhibition of apoptosis. Of the IAP family members, cIAP1, cIAP2, XIAP and survivin are known to be up-regulated in prostate cancer. BIRC6, a much l...

Journal: :Arthritis research & therapy 2015
Minna Turkkila Karin M E Andersson Sylvie Amu Mikael Brisslert Malin C Erlandsson Sofia Silfverswärd Maria I Bokarewa

INTRODUCTION Alternative splicing distinguishes normal and pathologic cells. High levels of oncoprotein survivin recognise patients with severe rheumatoid arthritis (RA). Here, we assess clinical relevance of alternative splicing of survivin in leukocytes of peripheral blood (PBMC) and bone marrow (BM) in RA patients. METHOD Transcription of survivin wild-type (survivin-WT), survivin-2B and s...

2014
Björn Svensson Ingiäld Hafström Malin C Erlandsson Kristina Forslind Maria I Bokarewa

INTRODUCTION High levels of the oncoprotein survivin may be detected in the majority of patients with early rheumatoid arthritis (RA). Survivin is a sensitive predictor of joint damage and persistent disease activity. Survivin-positive patients are often poor responders to antirheumatic and biological treatment. The aim of this study was to investigate the reproducibility of survivin status and...

2011
Gyu-Seok Cho Tae Sung Ahn Dongjun Jeong Jae-Jun Kim Chang-Jin Kim Hyun-Deuk Cho Dong-Kook Park Moo-Jun Baek

PURPOSE Recently, two alternatively spliced survivin variants, survivin-ΔEx3 and survivin-2B, were identified in a single copy of the survivin gene. It has been reported that the expressions of survivin splice variants significantly correlates with the clinical results in many types of human carcinoma. We investigated the transcription levels of survivin and its splice variants in human colorec...

Journal: :Cancer Research 2021

Abstract Substantial evidence has shown that overexpression of the inhibitor apoptosis protein (IAP) survivin in human tumors correlates significantly with treatment resistance and poor patient prognosis. Survivin serves as a radiation factor impacts DNA damage response by interacting DNA-dependent kinase (DNA-PKcs). However, complexity, molecular determinants, functional consequences this inte...

ژورنال: :مجله دانشگاه علوم پزشکی شهید صدوقی یزد 0
محمدعلی حسینپور فیضی ma hosseinpour feizi سولماز منیری جوادحصاری s moniri javadhesari اسماعیل بابائی e babaei وحید منتظری v montazeri منیره حلیمی m halimi

مقدمه: survivinعضو جدیدی از خانواده ی پروتئین های مهارکننده ی آپوپتوز (iap)می باشد که نقش مهمی در تنظیم چرخه ی سلولی و آپوپتوز ایفا می کند. بیان متمایز این ژن در سلول های توموری بر خلاف سلول های نرمال، آن را به عنوان چهارمین ترانس -کریپتوم عمده در تومورها معرفی کرده است. سرطان پستان شایع ترین بدخیمی در زنان می باشد و تلاش دانشمندان برای طبقه بندی آن به نتایج مختلفی منجر شده است. به دلیل شیوع بس...

Journal: :Oncology reports 2009
Guangying Qi Handan Tuncel Eriko Aoki Shinji Tanaka Sirou Oka Iwao Kaneko Mayumi Okamoto Maasaki Tatsuka Shiro Nakai Fumio Shimamoto

Survivin is a bifunctional protein that suppresses apoptosis and regulates cell division and is highly expressed in various human cancers. Recently, the intracellular localization of survivin in tumors has been suggested as a prognostic marker, but the molecular mechanisms are not understood. The aims of the present study were to investigate the different localization of survivin expression in ...

Journal: :Histology and histopathology 2007
G Pannone P Bufo R Serpico C Rubini R Zamparese F Corsi M C Pedicillo G Pannone S Staibano G De Rosa L Lo Muzio

Survivin is a recently described inhibitor of apoptosis and mitotic regulator which is selectively over-expressed in human tumors. Its expression rate is predictive of disease progression, early recurrences and resistance to therapy. Up-regulation of survivin in oral pre-malignant lesions (OPL) and in oral squamous cell carcinoma (OSCC) has already been demonstrated in previous studies. A criti...

Journal: :International journal of clinical and experimental pathology 2013
Michiko Shintani Akiko Sangawa Naoki Yamao Shingo Kamoshida

Survivin is a protein that is highly expressed in many embryonic tissues, as well as most human tumors. Prior studies have reported both positive and negative correlations between survivin expression and cancer prognosis, but these associations remain controversial. In the present study, we assessed the expression of nuclear and cytoplasmic survivin in gastrointestinal carcinomas. Using these d...

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