• Intracranial germinoma is the most common malignant intracranial germ cell tumor. It usually occurs in children and young adults and with the current therapies, many patients experience long-term survival. • Suprasellar region germinoma can present with isolated hypothalamic–pituitary axis dysfunction such as diabetes insipidus, delayed growth, menstrual irregularities, or precocious puberty,...

A patient with beta hCG-secreting germ cell carcinoma of the pineal and suprasellar regions presented with hydrocephalus, Parinaud's syndrome, hypopituitarism and polyuria. Central diabetes insipidus was strongly suspected although the water deprivation test was not diagnostic. The polyuria however, responded to ADH analogue when the hypothyroidism and hypocortisolism were treated. Pubertal dev...

In paediatric neurosurgery practice 1% of all intracrnaial space occupying lesions are arachnoid cysts (2.3). Suprasellar location of this uncommon pathology is rare. Following the introduction of computerized tomography (CT)to neurosurgical practice. a significant increase has been seen in suprasellar arachnoid cysts (SSAC) cases. Despite this fact. 109 cases have been reported in the literatu...

Shlomo Dotan, MD Department of Ophthalmology, Hebrew University Hadassah Medical Center, Jerusalem, Israel ABSTRACT Purpose: To demonstrate that slow-growing intracranial suprasellar mass lesions can be associated with optic disc cupping, clinically indistinguishable from glaucomatous optic neuropathy. Cases: At a neuro-ophthalmology tertiary clinic, a retrospective chart review identified four...

We report a pediatric patient who presented with hypogonadism and diabetes insipidus. Further evaluation revealed hypothyroidism. MRI of the brain revealed a suprasellar mass. Following frontal craniotomy for mass biopsy, histological analysis of the mass revealed benign lymphoid hyperplasia. The patient has had no progression of his mass or symptoms at most recent follow-up (10 months). We rev...

Trilateral retinoblastoma (TRb) is a rare combination of unilateral or bilateral retinoblastoma with an ectopic midline intracranial neuroblastic neoplasm (primitive neuroectodermal tumour) usually in the area of pineal gland or sellar region. TRb can occur with both familial and sporadic forms of retinoblastoma. An occurrence of this rare tumour in a 12-year-old boy who had unilateral retinobl...

Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant central nervous system neoplasm usually diagnosed in young children, although it can occur in adults. Prognosis for AT/RT is poor, with a median survival of 10 - 11 months. We report a rare case of adult sellar and suprasellar AT/RT in a 36-year-old female patient. She was treated with multi-modalities including surgery, chemotherap...

Germ cell tumors located in the central nervous system (CNS) represent less than 4% of the intracranial tumors and affect primarily children and young adults. These tumors frequently arise in the suprasellar and pineal region and in the midline structures around the third ventricle. Germ cell tumors can be divided as germinoma and nongerminomatous tumors regarding the histology. Only 5-10% of a...