BACKGROUND Insights into long-term clinical consequences of sulfur mustard have emerged from some investigations but less is known about the basic and molecular mechanisms of these complications. Sardasht-Iran Cohort Study is a comprehensive historical cohort study on Sardasht chemical victims' population which was designed to find out the long-term complications of sulfur mustard exposure and ...

Strain L mouse fibroblasts growing in vitro were exposed to varying concentrations of nitrogen and sulfur mustards, and the surviving fraction of cells was measured by their ability to form macroscopically visible colonies. Nitrogen mustard required 3 hours but sulfur mustard less than 1 hour to exert maximum killing effect. The mean lethal dose (D37) for nitrogen mustard acting for 1 hour on a...

Sulfur mustard is a chemical agent of high military and terroristic significance. No effective antidote exists, and sulfur mustard can be fairly easily produced in large quantity. Rapid field testing of sulfur mustard is highly desirable. Existing analytical devices for its detection are available but can suffer from low selectivity, laborious sample preparation, and/or the need for complex ins...

A line of cells (L/H) that was resistant to sulfur mustard has been isolated and compared in a number of ways to the parent line of L cells. Both strains had an average of 57 chromosomes. The L/H cells were smaller than the L cells, and contained lower concentrations of acid-soluble sulfhydryl compounds. In experi ments with sulfur mustard-36S, the whole cell, nucleus, and DXA of the resistant ...

For the past 15 years the international research community has conducted a basic and applied research program aimed at identifying a medical countermeasure against chemical threat vesicant, or blistering, agents. The primary emphasis of this program has been the development of therapeutic protection against sulfur mustard and its cutaneous pathology-blister formation. In addition to the work on...

BACKGROUND Sulfur mustard (SM) is a blister-forming agent that has been used as a chemical weapon. Sulfur mustard can cause damage in various organs, especially the skin, respiratory system, and eyes. Generally, the multiple complications of mustard gas result from its alkalizing potency; it reacts with cellular components like DNA, RNA, proteins, and lipid membranes.TGF-β is a multi-functional...

Sulfur mustard, a potent inhibitor of two-stage skin tumorigenesis, appears to act primarily by inactivating initiated cells rather than by suppressing the biochemical response to the promoter ^-O-tetradecanoylphorboMSacetate (TPA). Thus, when the increase of epidermal-dermal p-tosyl-L-arginine methyl ester esterase activity in TPAtreated mice was compared with the response of mice similarly tr...

background: despite almost the three decades passed since the chemical attacks of iraqi’s army against the iranian troops, some veterans are still suffering from long-term complications of sulfur mustard (sm) poisoning, including certain skin complaints specially dryness, burning, and pruritus. we thus aimed to evaluate the skin’s water and lipid content in patients with a disability of >25% du...

Sulfur mustard (SM) is a potent vesicant that has been employed as a chemical weapon in various conflicts during the 20th century. More recently, mustard was used in the Iraq conflict against Iranian troops and civilians. At the present time there are more than 40.000 people suffering from pulmonary lesions special bronchiolitis obliterans (BOs) due to mustard gas. SM increases the endogenous p...

background: sulfur mustard (sm) has acute and chronic effects on skin and mucosal surfaces. the aim of the study was to evaluate the frequency of esophagitis in a historical cohort of veterans who had been exposed to sm in iran-iraq war nearly 25 years ago.   methods : one hundred two veterans with dyspepsia and/or heartburn underwent esophago-gastro-duodenoscopy. of them, 52 cases had been exp...