A genetic polymorphism has been shown in man for the metabolism of isoniazid (Knight, Selin, and Harris, 1959; Evans, Manley, and McKusick, 1960; Sunahara et al., 1963a, b), and has been shown to control acetylation (Evans, 1962; Jenne, 1963; Evans and White, 1964; Peters, Miller, and Brown, 1965). The acetylation of sulphadimidine (sulfamethazine) has been found to be under the same genetic co...
