Apoptosis is a genetically controlled cellular response to developmental stimuli and environmental insult that culminates in cell death. Sublethal hyperoxic injury in rodents is characterized by a complex but reproducible pattern of lung injury and repair during which the alveolar surface is damaged, denuded, and finally repopulated by type 2 alveolar epithelial cells (AEC2). Postulating that a...

UNLABELLED Secondary bacterial infections increase disease severity of influenza virus infections and contribute greatly to increased morbidity and mortality during pandemics. To study secondary bacterial infection following influenza virus infection, mice were inoculated with sublethal doses of 2009 seasonal H1N1 virus (NIH50) or pandemic H1N1 virus (Mex09) followed by inoculation with Strepto...

The present study aimed at evaluating the anticancer and radiosensitizing potential of juglone against a chemoresistant and radioresistant tumor (B16F1 melanoma) growing on C57BL/6J mice. Volume doubling time, growth delay, and median survival were used to assess the in vivo anticancer and radiosensitizing potential of juglone. In vitro radiosensitizing potential of juglone was studied using cl...

The deformation of an erythrocyte has been observed microscopically in the shear flow to detect the sublethal damage of an erythrocyte in vitro. A rheoscope system has been manufactured to observe the deformation of the suspended erythrocytes in the shear flow. The rheoscope consists of a pair of parallel disks and an inverted phasecontrast microscope. The human erythrocytes were suspended in t...

Abstract Antibiotic-resistant bacteria severely threaten human health. Besides spontaneous mutations generated by endogenous factors, the resistance might also originate from induced certain antibiotics, such as fluoroquinolones. Such antibiotics increase genome-wide mutation rate introducing replication errors SOS response pathway or decreasing efficiency of DNA repair systems. However, relati...

widespread use of nanosilver can be led the contamination of aquatic environment and impact on living organisms such as fishes. we investigated histopathological changes in the gills tissue of caspian roach fingerlings after two weeks exposure to sublethal concentrations of nanosilver. following one and two weeks exposure, necrosis, shortening of secondary lamellae, edema, destruction of epithe...

PURPOSE Treatment of tumor cells by chemotherapy activates a series of responses ranging from apoptosis to premature senescence and repair. Survival responses are characterized by inhibition of cyclin-dependent kinases. Because inhibition of cyclin-dependent kinases represents a distinctive feature of DNA damage-induced prosurvival responses, we investigated the possibility that the cyclin-depe...