It was theoretically shown that impedance-like effects, called retroactivity, in biomolecular circuits can significantly impact the behavior of a system. In this paper, we quantify the effect of retroactivity on the transfer function of a phosphorylation system after linearization of its nonlinear model about a steady state. Our analysis shows that retroactivity shifts the poles of the transfer...

This is about a personal journey starting from my lifelong skepticism about statistical significance tests — perhaps the most mis-applied of all mathematical theories, especially as regards extreme events — toward a new clarity and power in the use of probability theory and a clear resolution of old dilemmas about subjectivity versus objectivity. There is little original thought here. Rather, t...

In this paper I address the question of whether the probabilities that appear in models of stochastic gene expression are objective or subjective. I argue that while our best models of the phenomena in question are stochastic models, this fact should not lead us to automatically assume that the processes are inherently stochastic. After distinguishing between models and reality, I give a brief ...

Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 426 I. A Very Brief Overview of Judicial Federalism in the Context of Criminal Process.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 428 II. Retroactivity Doctrine as Applied to Federal Constitutional New Rules.. . . . . . . . . . . . . . . . . . . . ...

• Studies show that interconnection of biological parts are vulnerable to Retroactivity, an effect that arises when an upstream system fails to preserve its input/output behavior upon connection to a downstream system. This effect alters both the dynamic as well as the steady state response of the upstream system. Abstract Impact of Retroactivity on Transcriptional Components Shridhar Jayanthi*...