BACKGROUND Tracheobronchopathia osteochondroplastica is a rare benign and often indolent disease. We report the first case of tracheobronchopathia osteochondroplastica (TBO) presenting as acute hypercarbic respiratory failure due to superimposed subglottic submucosal abscess. CASE REPORT A 27-year-old man presented to the emergency department in respiratory distress that required mechanical v...

PURPOSE To assess the efficacy of subglottic secretion drainage in preventing ventilator-associated pneumonia. METHODS We performed a comprehensive, systematic meta-analysis of randomized trials that have compared subglottic secretion drainage with standard endotracheal tube care in mechanically ventilated patients. Studies were identified by a computerized database search, review of bibliogr...

Acquired subglottic stenosis (a SGS) continues to pose great challenge to patients and clinicians due to lack of effective treatment strategies. Our understanding in pathophysiology of a SGS has significantly advanced in the past decades; however, much still remains to be elucidated. The purpose of this review is to describe current state of research in acquired subglottic stenosis, and discuss...

OBJECTIVE To evaluate the role of targeted cyclooxygenase-2 inhibition in reducing scarring associated with a subglottic airway mucosal injury. DESIGN Thirty-four New Zealand white rabbits underwent anterior cricothyroidotomy. Subglottic stenosis (SGS) was created by carbon dioxide laser injury. INTERVENTION Treatment consisted of intraperitoneal injection of celecoxib or vehicle for 4 days...

Introduction. Respiratory failure followed by endotracheal intubation can lead to severe post intubation laryngeal lesions in small group of patients. Complikations are classified as acute (early) and chronic on a base the laryngoscopy findings. Aim. To assess the statistical relationship between early post intubation complications and intubation duration, birth weight and gestational age. Mate...

BACKGROUND Recent studies have challenged the historically accepted fact that the larynx is cone-shaped in infants and children. The present study used computed tomography (CT)-based measurements to evaluate airway dimensions. The purpose of this investigation was to determine the dimensional transition between the subglottic area and the cricoid ring in children. METHODS This is a retrospect...

BACKGROUND Although clinical studies of the high-flow nasal cannula (HFNC) and its effect on positive end-expiratory pressure (PEEP) have been done, the washout effect has not been well evaluated. Therefore, we made an experimental respiratory model to evaluate the respiratory physiological effect of HFNC. METHODS An airway model was made by a 3D printer using the craniocervical 3D-CT data of...

We assessed several factors which might be responsible for the recurrence of post-intubation airway stenosis in a large group of patients who underwent resection and reconstruction surgery by one surgical team. Four hundred and ninety-four patients underwent reconstruction of post-intubation airway stenosis during 1995-2006. The case group comprised patients who had developed recurrence, while ...

OBJECTIVE To study the effect of subglottic secretions drainage on the incidence of ventilator-associated pneumonia (VAP) in patients receiving mechanical ventilation. DESIGN A randomized clinical trial. SETTING A 12-bed general ICU. PATIENTS One hundred fifty patients with an expected duration of mechanical ventilation > 72 h were enrolled in the study. INTERVENTION Patients were rando...

OBJECTIVES/HYPOTHESIS To investigate and treat the late complications of using nickel-titanium alloy stents in laryngotracheal, bronchial, and esophageal stenosis patients who developed severe laryngotracheal stenosis (SLS). STUDY DESIGN Retrospective clinical study. METHODS Thirteen patients with SLS or tracheoesophageal fistula secondary to insertion of a nickel-titanium alloy stent for t...