Objective: Our aim was to investigate the immunohistochemical expression of β-catenin and Sox-2 in adenomatous polyps adenocarcinoma colon also evaluate effects these markers adenoma-carcinoma sequence their association with clinicopathological parameters.
 Methods: Fifty-six tubular adenomas low grade dysplasia (TALGD), 53 high (TAHGD), 44 tubulovillous (TVA), 29 villous (VA) 60 adenocarc...

We have reported the use of the RCAS-TVA system to model sporadic tumorigenesis upon oncogenic activation in somatic mammary epithelial cells in the mouse. Here we review the advantages of this approach as compared to conventional mouse models with transgenic oncogene expression. We also in detail describe the RCAS-TVAmethod for introducing genes into somatic mammary epithelial cells engineered...

A complex interaction between the retroviral envelope glycoproteins and a specific cell surface protein initiates viral entry into cells. The avian leukosis-sarcoma virus (ALV) group of retroviruses provides a useful experimental system for studying the retroviral entry process and the evolution of receptor usage. In this study, we demonstrate that evolutionary pressure on subgroup A ALV [ALV(A...

Background: Even though tricuspid regurgitation (TR) is a frequent cardiac valve disorder, and annuloplasty (TVA) has been evolved to manage TR for more than 50 years, there still substantial controversy regarding the best durable method TVA. We reported our midterm (3 years) outcomes of TVA using autologous pericardial (AP) band comparing it with DeVega management functional TR.
 Methods:...

Abstract Glioblastoma (GBM) is the most common and deadliest type of brain tumor affecting adult central nervous system, carrying a median survival 14 months. In vivo syngeneic animal models GBM that recapitulate human are urgently needed to decipher glioma biology develop novel therapeutics, including immunotherapy. Here, we generated mouse glioblastoma stem cell line (RCAS-TVA-GSC01) through ...

Abstract
 Stock buyback during the Covid 19 pandemic in 2020 which is intended to encourage economy and increase stock prices that have decreased. To prove these expectations are achieved or not, this study examines differences abnormal returns (AR) of stocks trading volume activity (TVA) before after share buybacks with a sample 7 BUMN issuers who realized until end June 2020. Paired test...

The interactions between the subgroup A avian leukosis virus [ALV(A)] envelope glycoproteins and soluble forms of the ALV(A) receptor Tva were analyzed both in vitro and in vivo by quantitating the ability of the soluble Tva proteins to inhibit ALV(A) entry into susceptible cells. Two soluble Tva proteins were tested: the 83-amino-acid Tva extracellular region fused to two epitope tags (sTva) o...

RCAS avian viruses have been used to deliver oncogene expression and induce tumors in transgenic mice expressing the virus receptor TVA. Here we report the generation and characterization of a novel RCAS-Cre-IRES-PyMT (RCI-PyMT) virus designed to specifically knockout genes of interest in tumors generated in appropriate mutant mouse hosts. FGF receptor 1 (FGFR1) is a gene that is amplified in h...

Stearoyl-CoA desaturase (SCD) is a key enzyme that determines the composition and metabolic fate of ingested fatty acids, in particular the conversion of trans-vaccenic acid (TVA) to conjugated linoleic acid (CLA). The present study addressed the hypothesis that intestinal TVA absorption and biotransformation into CLA can be modulated by EPA and 3,10-dithia stearic acid (DSA) via altered SCD mR...