Background: Fibroepithelial tumors of the breast are a heterogeneous group biphasic lesions comprising an epithelial component and quantitatively predominant mesenchymal component. These classified into two major categories: Fibroadenoma phyllodes tumor (PT). Phyllodes benign, borderline malignant grade categories based on histological parameters.
 Methods: An analytical-cross sectional st...

Gastrointestinal Stromal Tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract and most commonly affects the stomach, while fibromatosis is a rare locally aggressive fibrous tissue neoplasm. There have been reports of GIST and fibromatosis occurring in same individual and in most of them fibromatosis occurs within the abdomen. In 75% of patients fibromatosis occurs aft...

BACKGROUND Stromal fibroblasts are important determinants of tumor cell behavior. They act to condition the tumor microenvironment, influence tumor growth, support tumor angiogenesis and affect tumor metastasis. Heparan sulfate proteoglycans, present both on tumor and stromal cells, interact with a large number of ligands including growth factors, their receptors, and structural components of t...

In Vitro Tumor Models The success of personalized cancer therapy hinges on a timely clinical decision and preclinical model that can recapitulate tumor stromal heterogeneity for clinically relevant drug profiling. article 2202279, Eliza Li Shan Fong co-workers review how by transcending the existential reductionist approaches, bioengineered patient-derived explant (PDE) models truly replicate f...

background: gastrointestinal stromal tumors (gists) constitute the majority of gastrointestinal mesenchymal tumors. they usually express a proto-oncogen protein called cd117 detected by immunohistochemistry. this study investigated the differentiation of gists as well as the risk of aggressive behaviors in gists from surgically-treated patients in university affiliated hospitals.   methods: the...

Objective: Accurate preoperative diagnosis and prognosis of a gastric stromal tumor is vital to its effective treatment. This study aimed to evaluate the value of endoscopic ultrasonography in gastric stromal tumor diagnosis and prognosis. Methods: We retrospectively analyzed 213 cases of gastric stromal tumor diagnosed preoperatively by endoscopic ultrasonography from June 2010 to June 2014, e...

The growth of solid tumors depends on tumor stroma. A single adoptive transfer of CD8(+) CTLs that recognize tumor antigen-loaded stromal cells, but not the cancer cells because of MHC restriction, caused long-term inhibition of tumor growth. T cells persisted and continuously destroyed CD11b(+) myeloid-derived, F4/80(+) or Gr1(+) stromal cells during homeostasis between host and cancer. Using ...

UNLABELLED Solid tumors are generally composed of two major components: heterogeneous malignant cells and non-malignant stromal part. The latter comprises several types of non-malignant cells of mesenchymal, endothelial and immune origin and together with the extracellular matrix significantly affects the biological properties of the tumor. This minireview is focused on recent advances in the u...

Communication between stromal cells and tumor cells initiates tumor growth, angiogenesis, invasion, and metastasis. Stromal cells include cancer-associated fibroblasts, tumor-associated macrophages, pericytes, endothelial cells, and infiltrating immune cells. MicroRNAs (miRNAs) in the tumor microenvironment have emerged as key players involved in the development of cancer and its progression. m...

Pancreatic ductal adenocarcinoma (PDAC) is marked by an abundant stromal deposition. This stroma is suspected to harbor both tumor-promoting and tumor-suppressing properties. This is underscored by the disappointing results of stroma targeting in clinical studies. Given the complexity of tumor-stroma interaction in PDAC, there is a need to identify the stromal proteins that are predominantly tu...