The content of estrogen and progesterone receptors (ER, PR) is higher in fibroid tissue than in homologous myometrium, and both receptors seem to be regulated by the levels of circulating sex steroids. Myometrial and fibroid tissues were recovered from women undergoing gynecological operations during different phases of the menstrual cycle and during treatment with an analogue of GnRH (GnRHa). ...

PURPOSE In intervillous space, thrombomodulin (TM) can be a key component of the protein C anticoagulant pathway that controls the balance between coagulation and anticoagulation/ /fibrinolysis via activation of protein C (APC). In our working hypothesis we assume that not only TM from the placenta, but also TM from myometrium might be engaged in this protective mechanism. To determine whether ...

Aberrant DNA methylation has been implicated in tumorigenesis. This study was undertaken to establish the genome-wide DNA methylation profile in uterine leiomyomas and to investigate whether DNA methylation status is altered in uterine leiomyomas. For this purpose, restriction landmark genomic scanning (RLGS) was performed on a paired sample of leiomyoma and adjacent normal myometrium. The RLGS...

Nitric oxide relaxes myometrium in a cGMP-independent manner. Although cGMP activates its cognate kinase, this is not required for the inhibitory effect of nitric oxide. Thus, nitric oxide-mediated cGMP elevation does not enjoy the same set of substrates as it does in other smooth muscles. To further understand the regulation of relaxation of uterine muscle by cGMP, we have studied the actions ...

The inhibitory impacts of RP 73401, a phosphodiesterase type 4 (PDE4) selective inhibitor of the second generation, versus rolipram, the prototypal PDE4 inhibitor, were evaluated and compared on cAMP phosphodiesterase (PDE) activity and contractility of the myometrium in nonpregnant and pregnant women. In enzymatic studies, RP 73401 and rolipram inhibited the cAMP PDE activity with significantl...

Glucocorticoid receptors must be complexed with Hsp90 in order to bind steroids, and it has been reported that at least three other proteins, Hop, Hsc70, and a J-domain protein (either Hsp40 or Ydj1), are required for formation of active Hsp90-steroid receptor complex. In the present study, we reinvestigated activation of stripped steroid receptors isolated from either L cells or WCL2 cells. Su...

This paper sketches the design and implementation of DeviceDriver Analyzer for x86 (DDA/x86), a prototype analysis tool for finding bugs in stripped Windows device-driver executables (i.e., when neither source code nor symbol-table/debugging information is available), and presents a case study. DDA/x86 was able to find known bugs (previously discovered by source-code-based analysis tools) along...

The diversity of the clinical picture and asymptomatic nature manifestations myometrial pathology cause difficulties in diagnosis. There is a lack reliable diagnostic criteria for this pathology, particular, imaging, especially with simultaneous combination adenomyosis leiomyoma.
 aim research. Determination possibility compression sonoelastography diagnosis determination its characteristi...