Objective(s): Diabetes mellitus is a public health problem and one of the five leading causes of death globally. In the present study, the effect of Metformin with natural honey was investigated on glycemia in the Streptozotocin-induced diabetic rats. Materials and Methods: Thirty Wistar male rats were randomly divided into six groups including C: non ‌diabetic rats received distilled water, C...

Highlights: This study observed the histology of pancreatic β-cell damage without any intervention to kidneys animal models. The histological analysis shows that STZ-induced models can be used for assessing kidney abnormalities due hyperglycemia. A scoring system was developed evaluate changes in cells. Abstract are one organs affected by microvascular complications diabetes mellitus. Hyperglyc...

Abstract Background and Aims Diabetic nephropathy (DN) is a major cause of mortality in patients with diabetes chronic kidney disease, but there lack effective therapeutic drugs for this disease. The development progression DN influenced by fibrosis. transforming growth factor (TGF)-β1 key cytokine involved fibrosis many different organ systems. Anti-fibrotic gene (Anti-F) TGF-β/Smad signaling....

This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insul...

The present study was undertaken to evaluate the possible protective effects of simvastatin (SMV) against oxidative stress in streptozotocin- (STZ)-induced diabetic rats. Diabetes was induced experimentally in rats by i.p. injection of STZ in a dose of 60 mg/kg bwt. After 5 weeks of STZ injection, there were apparent reductions in the animal body weight and significant increase in blood glucose...

Abstract Background Alpha-2u globulin nephropathy mainly shows toxicological pathology only in male rats induced by certain chemicals and drugs, such as levamisole (antiparasitic anticancer drugs). Streptozotocin (STZ) is also an anticancer-antibiotic agent that has been used for decades to induce a diabetic kidney disease model rodents. The purpose of this study determine if STZ causes alpha-2...

Neonatally streptozotocin-induced diabetic (n-STZ) rats were given food containing Lactobacilins GG cells (GG) er a control diet <control), from 9 to 18 weeks of age. The GG cells significantly lovvered the blood hemoglobin Aic (HbAic) level and improved glucose to]erance in n-STZ rats (p <O.05). In the GG group, the serum iitsulin level at 30 min after gl"cose loading was significantly higher ...

Rats with electroytic lesions of the ventromedial hypothalamus (VMX rats) and sham-operated controls (SHAM rats) were injected with streptozotocin (STZ) at a dose of 50 mg/kg 48 h after the lesions were made. VMX rats were significantly more sensitive to STZ in that over 70% died within 6 wk, shereas none of the SHAM rats dies. When smaller doses of STZ were given to VMX rats (30--35 mg/kg), a ...

Treatment of rats with streptozotocin (STZ, 45mg/kg, i.v.,single dose) produced cardinal symptoms of diabetes mellitus including hyperglycemia, hypoinsulinemia and increase in blood pressure. Treatment with losartan--an angiotensin (AT1) receptor antagonist, 2 mg/kg, po for 6 weeks decreased the blood glucose levels by 16.5%. There was 190% increase in AUCglucose and 59.4% decrease in AUCinsuli...

Parkia biglobosa seed an important household spice commonly consumed in Nigeria is believed to possess antioxidant activity that may exert modulatory effects in diabetes and diabetic complications. This study investigated the modulatory potential of Parkia biglobosa protein isolate (PBPi) on serum testosterone (sTT) level as well as its influence on biomarkers of oxidative stress in brain and t...