Isoniazid given orally readily and rapidly diffuses into the cerebrospinal fluid in health and disease (Fletcher, I952, 1953) and probably, also, gains access to tubercle bacilli within the cells. Adequate bacterio-static level of the isoniazid in the cerebrospinal fluid was found in both lower and higher doses. Throughout the illness Ritchie (I953) showed that isoniazid is more diffusible in t...

Klein, Dolph (Rutgers, The State University, New Brunswick, N. J.), and David Pramer. Bacterial dissimilation of streptomycin. J. Bacteriol. 82:505-510. 1961.-The influence of various nutritional and environmental factors on the dissimilation of streptomycin by a pseudomonad isolated from soil was investigated, and conditions most suitable for growth of the bacterium, in a medium that contained...

Extracts of streptomycin-producing strains of Sfreptomyces phosphorylate dihydrostreptomycin (sfrepfidino)phosphate with adenosine 5’-triphosphate as the phosphoryl donor. The second phosphate is esterified with the dihydrostreptobiosamine moiety. Streptomycin (sfreptidino)phosphate was not phosphorylated under similar conditions. Because of its lability, the new enzyme that is responsible for ...

In attempting to explain the results obtained when certain strains of Escherichia coli were treated with streptomycin, a reaction between pyruvate and oxalacetate was proposed as the sensitive reaction. The action of streptomycin on this reaction was regarded as being related to its action in inhibiting the organism since only antibiotically active forms of streptomycin were inhibitory and comp...

form of recent dental infection or manipulation.4 Our patient also had very poor dentition and valvular heart disease. Various combinations of antibiotics like penicillin and streptomycin, cephalosporin and streptomycin, penicillin, tetracycline and streptomycin have been successful in achieving cure, however, at present high dose penicillin (> 25 mU/day) in combination with an aminoglycoside f...

The simplicity and reproducibility which characterize the conversion of streptomycin to malt01 (1) by heating in dilute alkali have made this reaction the basis of a frequently used analytical method for streptomycin (2). When used in these laboratories as a method of assaying streptomycin preparations, however, the malt01 reaction consistently gave lower yields per unit of potency with pure st...