A 27-year-old patient with Churg Strauss syndrome (CSS) and polyneuropathy diagnosed five years ago, was admitted to our department with chronic bloody diarrhea for one year and iron deficiency anemia (Hb: 6.3 g/dL, ferritin 2.5 ng/mL, ESR: 13, CRP: 0.33 mg/dL). Upper gastrointestinal (GI) endoscopy was negative but the biopsies demonstrated eosinophilic infiltration of the lamina propria parti...

OBJECTIVE To assess the clinical features of nervous system (NS) involvement in patients with ANCA-associated vasculitides (AAV), including microscopic polyangiitis (MPA), Wegener's granulomatosis (WG), and Churg-Strauss syndrome (CSS). METHODS One hundred and seventy-nine patients admitted to Peking Union Medical College Hospital from 1995 to 2008, including 93 cases of MPA, 61 cases of WG, ...

OBJECTIVE To study the fetal and maternal outcome of pregnancy in patients with granulomatous vasculitis. METHODS Four pregnancies in two patients with Wegener's granulomatosis (WG) and one patient with Churg-Strauss syndrome (CSS) were identified and followed in our specialised clinic for pregnancy and connective tissue diseases. RESULTS Three pregnancies ended with live babies and one wit...

Eosinophilic myocarditis may be accompanied by Churg-Strauss syndrome (CSS). We report a case of CSS that was accompanied by myocardial changes in the early stage. A 71-year-old woman complained of mild chest pain at rest, but routine echocardiography did not reveal any endocardial abnormalities. Four months later, the patient was hospitalized due to congestive heart failure with neuropathy of ...

Context: Churg-Strauss syndrome (CSS) is a rare antineutrophil cytoplasmic antibody associated vasculitis characterized by asthma, chronic rhinosinusitis, and persistent eosinophilia. Although acute diarrhea is frequent clinical manifestations of parasitic infection, it is not a main clinical presentation of CSS. We report a 49-year-old man who presented with acute watery diarrhea and periphera...

BACKGROUND To obtain insight into the mechanisms of tissue injury in lung disease due to Churg-Strauss syndrome (CSS), the bronchoalveolar lavage (BAL) cell profile and the levels in the BAL fluid of cell products released by activated eosinophils and neutrophils were assessed. METHODS Thirteen patients with active progressive CSS (n = 7) or CSS in partial remission (n = 6) underwent clinical...

Propylthiouracil (PTU) is a frequently prescribed drug in the treatment of hyperthyroidism. The use of PTU is, however, accompanied by numerous potentially serious side effects including vasculitis. PTU-related vasculitides can present as haematuria, pulmonary haemorrhage, or cutaneous lesion together with aspecific symptoms such as fever, myalgia, arthralgia, and fatigue. Cerebral involvement ...

Churg-Strauss syndrome (CSS) is a granulomatous necrotizing vasculitis of unknown etiology associated with bronchial asthma. Despite affecting small to medium-sized vessels, necrosis of the digits due to vasculitis is extremely rare. We report a case of CSS with necrosis of the toe tips. A 37-year-old woman with asthma, who had been diagnosed with CSS 2 years ago, was admitted to our hospital w...

Churg-Strauss syndrome (CSS) is a rare multi-system vasculitis; some cases have been reported in Korea. The aim of this study is to describe the clinical features, treatment outcome, and long-term follow-up of CSS from a single Korean medical center. Between 1995 and 2004, seventeen patients were diagnosed with CSS at the Department of Medicine of the Samsung Medical Center, Sungkyunkwan Univer...

We describe 3 siblings who suffered from marked eosinophilia with organ involvement. One sibling, who experienced cervical lymphadenopathy and peripheral neuropathy with eosinophilia (5,834 cells/μL) following bronchial asthma, was diagnosed with Churg-Strauss syndrome (CSS) according to the criteria of the American College of Rheumatology. Another sibling, who suffered from severe asthma with ...