Circulating factors, such as agonistic autoantibodies to the angiotensin II type 1 (AT1) receptor (AT1-AAs), and inflammatory cytokines, including tumor necrosis factor (TNF), are suggested to be important links between placental ischemia and hypertension in preeclamptic women. The purpose of this study was to determine the role of placental ischemia and TNFin stimulating the AT1-AA and the imp...

background and objectives: during past decades hansenula polymorpha has attracted global attention for the expression of recombinant proteins due to its high growth rate, minimal nutritional porequirements and use of methanol as a low cost inducer. materials and methods: the corresponding nucleotide sequences for the expression of heterologous genes in hansenula poylmorpha were extracted and as...

Bioaccumulation of Cu, Zn, Hg in muscles and liver tissues of stellate sturgeon (Acipenser stellatus) from the southern Caspian Sea was measured. Effects of condition factor (CF), age and hepatosomatic index (HSI) on metal accumulation were also determined. Some 40 stellate sturgeons were collected using gill nets in winter and spring 2007-2008 from the southern shores of the Caspian S...

Acid-stimulating action and clearance of pure natural human big gastriin (HG-34-I) and little gastrin (HG-17-I) were assessed in four male subjects with inactive duodenal ulcer (DU) disease. Disappearance half-times for HG-17-I after intravenous infusion (5.2 min) or rapid intravenous injection (6.4 min) were six to eight times shorter than those for HG-34-I (41.5 and 37.8 min, respectively). S...

Soluble receptor for advanced glycation end products (sRAGE) acts as a decoy sequestering of RAGE ligands, thus preventing the activation ligand-RAGE axis linking human diseases. However, molecular mechanisms underlying sRAGE remain unclear. In this study, THP-1 monocytes were cultured in normal glucose (NG, 5.5 mmol/L) and high (HG, 15 to investigate effects diabetes-relevant concentrations on...

fusion of two genes at dna level produces a single protein, known as a chimeric protein. immunotoxins are chimeric proteins composed of specific cell targeting and cell killing moieties. bacterial or plant toxins are commonly used as the killing moieties of the chimeric immunotoxins. in this investigation, the catalytic domain of shiga-like toxin (a1) was fused to human granulocyte macrophage c...

abstract background: recently, stem cells have been used to facilitate healing in animal models of renal failure induced by acute ischemic and nephrotoxic damage. granulocyte colony-stimulating factor (g-csf) has been reported to stimulate stem cell mobilization from bone marrow and these cells may contribute to renal repair. objectives: in the present study, the effects of g-csf and stem cell ...