Chenodiol is an important bile acid widely used for gallstone dissolution and cholestatic liver diseases. We succeeded in a short-step synthesis of chenodiol, starting from the safer phytosterol, stigmasterol.

A new furofuranic lignan named (+)-epimembrine together with known (+)-epieudesmine and (+)-epimagnoline were isolated from leaves of R. mucosa. Their structures were determined by spectroscopic data. Palmitone and a mixture of beta-sitosterol and stigmasterol were also isolated.

Background: Cancer is one of the biggest health problems worldwide, with lung cancer as first rank in number new cases and deaths. Non-small cell carcinoma (NSCLC) a type that accounts for about 85% all cases. Previous research identified role epidermal growth factor receptor (EGFR) most suitable target to treat NSCLC. This study aims identify potential compounds derived from mangrove plants ag...

Four phytoecdysteroids: (20-hydroxyecdysone-20, 22-monacetonide (1), 20-hydroxyecdysone (2), stigmasterol (3), gamma-sitosterol (4), were investigated for toxic effect against 3 rd /4 th instar larvae of Anopheles gambiae under laboratory conditions as individual compounds and in blends. The test larvae were treated with solutions containing the phytoecdysteroids of concentrations 1, 5 and 10pp...

Alcohols and hydrogen peroxide altered the permeability of membranes of Beta vulgaris root cells. Generally alcohols increased the permeability of membranes without going through an induction period except methanol which required a 10- to 15-hour induction period. The membrane effect of methanol could be inhibited with CaCl(2), cholesterol, beta-sitosterol, and stigmasterol. Cholesterol was the...

Pueraria tuberosa (Roxb. ex. Willd.) DC. (Fabaceae) is the important plant used in Indian medicine, commonly known as Vidarikand. The plant is described as rasayana and tonic in Ayurvedic Pharmacopoeia of India (1). It is an extensive perennial climber, growing throughout tropical parts of India, mostly in moist regions, monsoon-forests and coastal tracts (2). The tuber of pueraria is sweet in ...

Cattle encephalon glycoside and ignotin injection offers neural protection after cerebral apoplexy clinically, but the exact mechanism of the protective effect is unclear. We performed primary culture of neurons and astrocytes and simulated ischemic brain damage using AAPH and discussed the action mechanism of cattle encephalon glycoside and ignotin injection. Results showed that cattle encepha...