The relationship between formation of exogenous alanine and the establishment of nonsmooth variants in originally smooth cultures of Brucella abortus strains has been clearly demonstrated (Goodlow et al., 1950). Furthermore, the addition of D-alanine to smooth cultures in synthetic medium (Gerhardt and Wilson, 1948) results in earlier establishment of nonsmooth cells (Goodlow et al., 1951). Sub...

Many properties of chemicals depend on their stereochemistry. Among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. We have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. As, depending on their lipophilicity, penetration enhancers can change ...

Many properties of chemicals depend on their stereochemistry. Among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. We have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. As, depending on their lipophilicity, penetration enhancers can change ...

Abstract Series of linear tridentate PN Ph P R ‐ligands (R=Me, Et, Pln, Ph, Cyp, i Pr, Cy, t Bu) and molybdenum tricarbonyl complexes [Mo(CO) 3 ] (R=Ph, Cy,) were synthesized characterized using NMR‐, IR‐, Raman spectroscopy as well X‐ray crystallography. The influence the different phosphine donor groups ligands on bonding activation CO is investigated. Importantly, all are found to adopt a fa...

Perioperative seizures have numerous potential etiologies. In general, when seizures occur during surgery, their onset often coincides with the introduction of a specific anesthetic or analgesic drug. Conversely, postoperative seizures are more commonly due to nonanesthetic causes. However, there have been reports of postoperative convulsions that appeared to be caused by anesthetic or analgesi...

many properties of chemicals depend on their stereochemistry. among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. we have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. as, depending on their lipophilicity, penetration enhancers can change ...

Abstract Background: Herbal remedies are widely available and whilst portrayed as generally harmless, they may contain a variety of potent medications that can cause unintended potentially serious consequences. This danger is further amplified their use typically inadvertently not divulged to clinicians, such in this case. Clinical Case: A 65-year-old gentleman was referred Endocrinology for as...

Sphingolipids is characterized to be composed of a unique fatty amino alcohol, so-called long-chain base (LCB) or sphingoid base, most of which are linked to a fatty acid via amide bond to form ceramide and more complex sphingolipids following further glycosylation and/or phosphorylation of the ceramide backbone (Figure 1). Sphingolipids are conserved ubiquitously in eukaryotes and a few specie...

Understanding isomerization in nanoparticles at the atomic level is critical to expanding diversity of nanomaterials. In this issue Chem, Xie, Häkkinen, and co-workers describe a new approach realizing reversible isomeric transformation an atomically precise gold nanocluster by engineering intermolecular interactions between cationic surfactants anionic ligands on cluster surface. Isomers, form...

Diamond hydrocarbons (or diamondoids) are hydrocarbons that have a carbon skeleton superimposable on the diamond lattice and contain one or more adamantane units. Recently it was found that many higher diamondoids (containing four to eleven adamantane units) are present in petroleum and can be isolated by a series of methods that include HPLC and GC techniques. We develop QSPR equations using m...