Acquired tracheal stenosis remains a challenging problem for otolaryngologists. The objective of this study was to determine whether the Sendai virus (SeV)-mediated c-myc suppressor, a far upstream element (FUSE)-binding protein (FBP)-interacting repressor (FIR), modulates wound healing of the airway mucosa, and whether it prevents tracheal stenosis in an animal model of induced mucosal injury....

Loss-of-function mutations in the sevenless (sev) gene in Drosophila result in the failure to differentiate a specific photoreceptor cell type--namely, the R7 cell. The sev gene encodes a cell-surface receptor tyrosine kinase that functions in the presumptive R7 cell to transduce developmental cues from its neighbors, instructing it to differentiate along the R7 cell pathway. We have isolated t...

Detecting areas with high social-ecological vulnerability (SEV) is essential to better inform management interventions for building resilience in coastal systems. The SEV framework, developed by the Intergovernmental Panel on Climate Change, a robust method identify of tropical systems climate change. Yet, application this framework temperate regions and other drivers change remains underexplor...

In recent years, in various sectors of our society, there have been nationalist stirrings which were crystallized and articulated by the late Claro M. Recto, There were jealous demands for the recognition of Philippine sovereignty on the Bases question. There were appeals for the correction of the iniquitous economic relations between the Philippines and the United States. For a time, Filipino ...

Lactate or gas exchange threshold (GET) and critical power (CP) are closely associated with human exercise performance. We tested the hypothesis that the limit of tolerance (Tlim) during cycle exercise performed within the exercise intensity domains demarcated by GET and CP is linked to discrete muscle metabolic and neuromuscular responses. Eleven men performed a ramp incremental exercise test,...

Sendai virus (SeV) is highly pathogenic for mice. In contrast, mice (including SCID mice) infected with simian virus 5 (SV5) showed no overt signs of disease. Evidence is presented that a major factor which prevented SV5 from productively infecting mice was its inability to circumvent the interferon (IFN) response in mice. Thus, in murine cells that produce and respond to IFN, SV5 protein synth...

Abstract Objective To explore the adipogenic effects of small extracellular vesicles derived from lipoma tissues (sEV-LT), and to find a new cell-free therapeutic approach for adipose tissue regeneration. Methods Adipose tissue-derived stem cells (ADSCs) (sEV-AT) were isolated human tissue, while sEV-LT lipomatous tissue. ADSCs characterized by using flow cytometric analysis osteogenic differen...

Values of Dirichlet L-functions at s = 1 have always attracted great attention due to their central role in number theory. In particular the prime number theorem for arithmetic progressions relies on the non-vanishing of L(1, χ) for any non-principal character χ (mod q). Moreover improving the existing lower bounds for |L(1, χ)| (the famous Siegel’s bound |L(1, χ)| ≫ǫ q) would imply many import...