نتایج جستجو برای: stat 6

تعداد نتایج: 965805  

2004
I Monteleone G Monteleone G Del Vecchio Blanco P Vavassori S Cucchiara T T MacDonald F Pallone

Background: In coeliac disease (CD) mucosa, the histological lesion is associated with marked infiltration of T helper cell type 1 (Th1) cells. However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown. Aims: To analyse expression of transcription factors which control the Th1 cell commitment in CD. Patients: Duodenal mucosal samples were taken from untr...

Journal: :Physical review letters 2004
B Aubert R Barate D Boutigny J-M Gaillard A Hicheur Y Karyotakis J P Lees P Robbe V Tisserand A Zghiche A Palano A Pompili J C Chen N D Qi G Rong P Wang Y S Zhu G Eigen I Ofte B Stugu G S Abrams A W Borgland A B Breon D N Brown J Button-Shafer R N Cahn E Charles C T Day M S Gill A V Gritsan Y Groysman R G Jacobsen R W Kadel J Kadyk L T Kerth Yu G Kolomensky G Kukartsev C LeClerc M E Levi G Lynch L M Mir P J Oddone T J Orimoto M Pripstein N A Roe A Romosan M T Ronan V G Shelkov A V Telnov W A Wenzel K Ford T J Harrison C M Hawkes D J Knowles S E Morgan R C Penny A T Watson N K Watson K Goetzen H Koch B Lewandowski M Pelizaeus K Peters H Schmuecker M Steinke J T Boyd N Chevalier W N Cottingham M P Kelly T E Latham C Mackay F F Wilson K Abe T Cuhadar-Donszelmann C Hearty T S Mattison J A McKenna D Thiessen P Kyberd A K McKemey L Teodorescu V E Blinov A D Bukin V B Golubev V N Ivanchenko E A Kravchenko A P Onuchin S I Serednyakov Yu I Skovpen E P Solodov A N Yushkov D Best M Bruinsma M Chao I Eschrich D Kirkby A J Lankford M Mandelkern R K Mommsen W Roethel D P Stoker C Buchanan B L Hartfiel J W Gary B C Shen K Wang D Del Re H K Hadavand E J Hill D B MacFarlane H P Paar Sh Rahatlou V Sharma J W Berryhill C Campagnari B Dahmes N Kuznetsova S L Levy O Long A Lu M A Mazur J D Richman W Verkerke T W Beck J Beringer A M Eisner C A Heusch W S Lockman T Schalk R E Schmitz B A Schumm A Seiden M Turri W Walkowiak D C Williams M G Wilson J Albert E Chen G P Dubois-Felsmann A Dvoretskii D G Hitlin I Narsky T Piatenko F C Porter A Ryd A Samuel S Yang S Jayatilleke G Mancinelli B T Meadows M D Sokoloff T Abe F Blanc P Bloom S Chen P J Clark W T Ford U Nauenberg A Olivas P Rankin J Roy J G Smith W C Van Hoek L Zhang J L Harton T Hu A Soffer W H Toki R J Wilson J Zhang R Aleksan S Emery A Gaidot S F Ganzhur P-F Giraud G Hamel De Monchenault W Kozanecki M Langer M Legendre G W London B Mayer G Schott G Vasseur Ch Yeche M Zito D Altenburg T Brandt J Brose T Colberg M Dickopp A Hauke H M Lacker E Maly R Müller-Pfefferkorn R Nogowski S Otto J Schubert K R Schubert R Schwierz B Spaan D Bernard G R Bonneaud F Brochard J Cohen-Tanugi P Grenier Ch Thiebaux G Vasileiadis M Verderi A Khan D Lavin F Muheim S Playfer J E Swain M Andreotti V Azzolini D Bettoni C Bozzi R Calabrese G Cibinetto E Luppi M Negrini L Piemontese A Sarti E Treadwell F Anulli R Baldini-Ferroli A Calcaterra R De Sangro D Falciai G Finocchiaro P Patteri I M Peruzzi M Piccolo A Zallo A Buzzo R Capra R Contri G Crosetti M Lo Vetere M Macri M R Monge S Passaggio C Patrignani E Robutti A Santroni S Tosi S Bailey M Morii E Won R S Dubitzky U Langenegger W Bhimji D A Bowerman P D Dauncey U Egede J R Gaillard G W Morton J A Nash P Sanders G P Taylor G J Grenier S-J Lee U Mallik J Cochran H B Crawley J Lamsa W T Meyer S Prell E I Rosenberg J Yi M Biasini M Pioppi M Davier G Grosdidier A Höcker S Laplace F Le Diberder V Lepeltier A M Lutz T C Petersen S Plaszczynski M H Schune L Tantot G Wormser V Brigljević C H Cheng D J Lange D M Wright A J Bevan J R Fry E Gabathuler R Gamet M Kay D J Payne R J Sloane C Touramanis J J Back C M Cormack P F Harrison H W Shorthouse P B Vidal C L Brown G Cowan R L Flack H U Flaecher S George M G Green A Kurup C E Marker T R McMahon S Ricciardi F Salvatore G Vaitsas M A Winter D Brown C L Davis J Allison N R Barlow R J Barlow P A Hart M C Hodgkinson F Jackson G D Lafferty A J Lyon J H Weatherall J C Williams A Farbin A Jawahery D Kovalskyi C K Lae V Lillard D A Roberts G Blaylock C Dallapiccola K T Flood S S Hertzbach R Kofler V B Koptchev T B Moore S Saremi H Staengle S Willocq R Cowan G Sciolla F Taylor R K Yamamoto D J J Mangeol P M Patel S H Robertson A Lazzaro F Palombo J M Bauer L Cremaldi V Eschenburg R Godang R Kroeger J Reidy D A Sanders D J Summers H W Zhao S Brunet D Cote-Ahern P Taras H Nicholson G Raven L Wilden C Cartaro N Cavallo G De Nardo F Fabozzi C Gatto L Lista P Paolucci D Piccolo C Sciacca C P Jessop J M LoSecco T A Gabriel B Brau K K Gan K Honscheid D Hufnagel H Kagan R Kass T Pulliam Q K Wong J Brau R Frey C T Potter N B Sinev D Strom E Torrence F Colecchia A Dorigo F Galeazzi M Margoni M Morandin M Posocco M Rotondo F Simonetto R Stroili G Tiozzo C Voci M Benayoun H Briand J Chauveau P David Ch De la Vaissière L Del Buono O Hamon M J J John Ph Leruste J Ocariz M Pivk L Roos J Stark S T'Jampens G Therin P F Manfredi V Re P K Behera L Gladney Q H Guo J Panetta C Angelini G Batignani S Bettarini M Bondioli F Bucci G Calderini M Carpinelli V Del Gamba F Forti M A Giorgi A Lusiani G Marchiori F Martinez-Vidal M Morganti N Neri E Paoloni M Rama G Rizzo F Sandrelli J Walsh M Haire D Judd K Paick D E Wagoner G Cavoto N Danielson P Elmer C Lu V Miftakov J Olsen A J S Smith H A Tanaka F Bellini R Faccini F Ferrarotto F Ferroni M Gaspero M A Mazzoni S Morganti M Pierini G Piredda F Safai Tehrani C Voena S Christ G Wagner R Waldi T Adye N De Groot B Franek N I Geddes G P Gopal E O Olaiya S M Xella M V Purohit A W Weidemann F X Yumiceva D Aston R Bartoldus N Berger A M Boyarski O L Buchmueller M R Convery D P Coupal D Dong J Dorfan D Dujmic W Dunwoodie R C Field T Glanzman S J Gowdy E Grauges-Pous T Hadig V Halyo T Hryn'ova W R Innes M H Kelsey

We present a study of B--->D(0)(CP)K- decays, where D(0)(CP) is reconstructed in CP-even channels, based on a sample of 88.8 x 10(6) Upsilon(4S)-->BB decays collected with the BABAR detector at the PEP-II e(+)e(-) storage ring. We measure the ratio of Cabibbo-suppressed to Cabibbo-favored branching fractions B(B--->D(0)(CP)K-)/B(B--->D(0)(CP)pi(-))=[8.8+/-1.6(stat)+/-0.5(syst)]x10(-2) and the C...

Journal: :The Journal of biological chemistry 1997
J Molden Y Chang Y You P S Moore M A Goldsmith

The present studies analyzed the biologic activity of a gene product (vIL-6) encoded by the recently discovered Kaposi's sarcoma-associated herpesvirus (KSHV) bearing 24.8% amino acid identity with human interleukin-6 (huIL-6). Based on this similarity, we hypothesized that this viral homolog might trigger the JAK/STAT pathway, which typically is engaged by IL-6 and other cytokines. Activation ...

Journal: :Gut 2004
I Monteleone G Monteleone G Del Vecchio Blanco P Vavassori S Cucchiara T T MacDonald F Pallone

BACKGROUND In coeliac disease (CD) mucosa, the histological lesion is associated with marked infiltration of T helper cell type 1 (Th1) cells. However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown. AIMS To analyse expression of transcription factors which control the Th1 cell commitment in CD. PATIENTS Duodenal mucosal samples were taken from unt...

2017
Man-Qing Liu Min Zhao Wen-Hua Kong Li Tang Fang Wang Ze-Rong Zhu Xia Wang Hong-Yan Qiu Dun-Jin Zhou Xu Wang Wen-Zhe Ho Wang Zhou

JAK-STAT signaling pathway has a crucial role in host innate immunity against viral infections, including HIV-1. We therefore examined the impact of HIV-1 infection and combination antiretroviral therapy (cART) on JAK-STAT signaling pathway. Compared to age-matched healthy donors (n = 18), HIV-1-infected subjects (n = 18) prior to cART had significantly lower expression of toll-like receptors (...

2002
Florence Legendre Jayesh Dudhia Jean-Pierre Pujol Patrick Bogdanowicz Sandra Pellegrini

Signal transducers and activators of transcription (STAT) factors are cytoplasmic proteins that can be activated by Janus kinases (JAK) and that modulate gene expression in response to cytokine receptor stimulation. STAT proteins dimerize, translocate into the nucleus, and activate specific target genes. In the present study, we show for the first time that Interleukin-6, in the presence of its...

2014
Georgia Levidou Sotirios Sachanas Gerassimos A Pangalis Christina Kalpadakis Xanthi Yiakoumis Maria Moschogiannis Athanasia Sepsa Eleftheria Lakiotaki Vassilis Milionis Marie-Christine Kyrtsonis Theodoros P Vassilakopoulos Pantelis Tsirkinidis Flora Kontopidou Styliani Kokoris Marina Siakantaris Maria Angelopoulou Helen Papadaki Nikolaos Kavantzas Panayiotis Panayiotidis Efstratios Patsouris Penelope Korkolopoulou

A number of studies have looked into the pathophysiological role of angiogenesis in CLL, but the results have often been inconsistent. We aimed to gain direct insight into the angiogenic process in lymph nodes involved by CLL, focusing on proangiogenic cytokines and microvessel morphometry. The tissue levels of VEGF, Th-2 cytokines IL-6 and IL-8, IL-8 receptor CXCR2, and tyrosine p-STAT-3/SOCS-...

2010
FELIX WICK Felix Wick

The observation of a narrow structure near the J/ψ φ threshold in exclusive B → J/ψ φK decays produced in pp̄ collisions at √ s = 1.96TeV is reported. A signal of 19 ± 6(stat) ± 3(syst) events, with statistical significance of 5.0 standard deviations, is seen in a data sample corresponding to an integrated luminosity of 6.0 fb, collected by the CDF II detector. The mass and natural width of the ...

2014
Luciana S. Oliveira Nina M. G. P. de Queiroz Laura V. S. Veloso Thaís G. Moreira Fernanda S. Oliveira Matheus B. H. Carneiro Ana M. Faria Leda Q. Vieira Sérgio C. Oliveira Maria F. Horta

C57BL/6 mice macrophages innately produce higher levels of NO than BALB/c cells when stimulated with LPS. Here, we investigated the molecular events that account for this intrinsic differential production of NO. We found that the lower production of NO in BALB/c is not due to a subtraction of L-arginine by arginase, and correlates with a lower iNOS accumulation, which is independent of its degr...

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