The prevalence of neurodegenerative diseases in all societies increases steadily and so do the costs for comprehensive scientific proteomics studies. This is due to immense expenses for equipment and consumables as well as to a high number of repetitions to fulfill the statistical imperative. At the same time, techniques become even more complex, whereas suitable samples are scarce, especially ...

INTRODUCTION Pregnancy induced hypertension (PIH), especially preeclampsia, is a state of extremely increased oxidative stress (OS), due to decrease of antioxidant capacity in comparison to normotensive pregnant women. The consequences of increased state of oxidative stress with hypertension disorder in pregnancy are disorder of placental blood flow, intrauterine hypoxia of the fetus and distur...

Objective: Evaluating the effect of antenatal betamethasone on the biophysical profile and Doppler indices of umbilical and middle cerebral arteries. Materials and Methods: Twenty-five preterm labor singleton pregnancies (gestational age, 26-34 weeks) were studied prospectively. These patients received two consecutive doses of betamethasone 24 hours apart to accelerate pulmonary maturation. Fet...

Dear Editor, Maternal complaint of decreased fetal movement is one of the alarms, which its delayed reporting could be associated with adverse pregnancy outcome. 1 Controlled trials have shown that fetal movement counting by the mother is the only promising antepartum test to reduce the mortality. 2 Reduction of fetal movement could be a marker of poor conditions like fetal hypoxia, stillbirth ...

In most vertebrate neurons, spikes initiate in the axonal initial segment (AIS). When recorded in the soma, they have a surprisingly sharp onset, as if sodium (Na) channels opened abruptly. The main view stipulates that spikes initiate in a conventional manner at the distal end of the AIS, then progressively sharpen as they backpropagate to the soma. We examined the biophysical models used to s...