DNA topoisomerase II (Top2) is the target of some of the most effective anticancer DNA intercalators. To determine the effect of intercalating ligands at defined positions relative to a known DNA cleavage site for human Top2alpha, we synthesized oligodeoxynucleotides containing single trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide (DE) deoxyadenosine (dA) adducts of known absolute configurat...

In this work a response surface approach was used for predicting the hill chart of a small horizontal shaft Kaplan turbine. To this aim, artificial neural networks (ANN) were chosen as a fast, reliable, and computationally inexpensive tool. The training of the ANN was based on computational fluid dynamics (CFD). The optimization of the runner-guide vane stagger correlation is a time consuming a...

Abstract The flow distortion at core engine entry for a variable pitch fan (VPF) in reverse thrust mode is described from realistic field obtained using an integrated airframe-engine model. model includes the VPF, splitter, complete bypass nozzle path wrapped nacelle, and installed to airframe landing configuration through pylon. A moving ground plane mimic rolling runway included. 3D Reynolds-...

background: abnormal angulation of the lunate can be an indication of intercarpal pathology. on magnetic resonance images (mris) the lunate often looks dorsally angulated, even in healthy wrists. the tilt on individual slices can also be different and might be misinterpreted as pathological, contributing to inaccurate diagnoses and unnecessary surgery. the primary aim of this study was to deter...

conclusions although some of the orthopedic surgeons are not interested to manage these fractures surgically and most of them treat these cases conservatively (casting, etc.), in most displaced intra-articular calcaneal fractures, surgical treatment is the method of choice. moreover, in non-surgical treatment the prevalence of these complications among the patients is more and as a result, inev...

In this paper, we experiment with using Stagger, an open-source implementation of an Averaged Perceptron tagger, to tag Icelandic, a morphologically complex language. By adding languagespecific linguistic features and using IceMorphy, an unknown word guesser, we obtain stateof-the-art tagging accuracy of 92.82%. Furthermore, by adding data from a morphological database, and word embeddings indu...

This paper describes work in progress. We experiment with training a state-of-the-art tagger, Stagger, on a new gold standard, MIM-GOLD, for the PoS tagging of Icelandic. We compare the results to results obtained using a previous gold standard, IFD. Using MIM-GOLD, tagging accuracy is considerably lower, 92.76% compared to 93.67% accuracy for IFD. We analyze and classify the errors made by the...