In this paper we consider the bilevel programming problem (BLPP), which is a sequence of two optimization problems where the constraint region of the upper-level problem is determined implicitly by the solution set to the lower-level problem. We extend well-known constraint qualifications for nonlinear programming problems such as the Abadie constraint qualification, the Kuhn-Tucker constraint ...

Biomarkers have the potential to expedite drug development, increase patient safety, and optimize clinical response. Yet few have achieved regulatory qualification. A survey was conducted to clarify industry's perspective on biomarker qualification and identify the most promising biomarkers for drug development. The results across toxicities/clinical areas highlight challenges in regulatory qua...

‎In this paper, using the idea of convexificators, we study boundedness and nonemptiness of Lagrange multipliers satisfying the first order necessary conditions. We consider a class of nons- mooth fractional programming problems with equality, inequality constraints and an arbitrary set constraint. Within this context, define generalized Mangasarian-Fromovitz constraint qualification and sh...

The current study aimed to identify the traits of leading principal from perspective administrative and instructional staff in secondary schools al- Karak. used descriptive survey method collect data, a 44- item questionnaire was developed measure teaching al-Karak. It divided into three fields: namely: personal school - (16) items, field human (14) social principal- items. applied sample consi...

Background: Biomedical waste (BMW) management have become a significant concern for health care providers as it carries higher potential infection and injury. Inappropriate knowledge of handling healthcare may serious consequences. There is an urgent need raising awareness BMWM among the hospital staff in all setups. Effective biomedical not only legal necessity but also social responsibility. ...

Dual characterizations of the containment of a convex set with quasiconvex inequality constraints are investigated. A new Lagrange-type duality and a new closed cone constraint qualification are described, and it is shown that this constraint qualification is the weakest constraint qualification for the duality.

Most developed countries have already accepted‘’ Competency’’ as the major factor in making management more competitive, therefore they have discovered the importance of Qualification Models and their application to cause human resources growth. Consequently, their aim is to improve the qualification of their human resources, and to reach this end, considering different ways of assessing compet...