A La Niña took place in the equatorial Pacific in 1999, and strong tropical instability waves (TIWs) developed, causing large meanders of a sea surface temperature (SST) front between the equator and 3◦N. High-resolution satellite measurements are used to describe the variability of SST, surface wind velocity, column-integrated water vapor, cloud liquid water and precipitation associated with t...

The newly developed multireceptor somatostatin analogs pasireotide (SOM230), octreotide and somatoprim (DG3173) have primarily been characterized according to their binding profiles. However, their ability to activate individual somatostatin receptor subtypes (sst) has not been directly assessed so far. Here, we transplanted the carboxyl-terminal phosphorylation motif of the sst(2) receptor to ...

The Tropical Rainfall Measuring Mission (TRMM) Microwave Imager (TMI) with the capability of measuring sea surface temperature (SST) in the presence of clouds, has been providing an unprecedented view of tropical basin-scale SST variability. In this paper, an assessment of the accuracy of the SST derived from TMI over the Bay of Bengal using in situ data collected from moored buoys and research...

Cushing’s disease is Cushing’s syndrome caused by an adrenocorticotropic hormone-secreting pituitary adenoma and, in the absence of adequate treatment, can be fatal. Cushing’s disease represents an unmet medical need, with no approved medical therapies. Pasireotide is a novel multi-receptor-targeted somatostatin analogue with high affinity for sst 1,2,3 and sst 5 . Compared with octreotide, pas...

Short term forecasts of meteorological parameters (including precipitation) over the oceans is often difficult because of the lack of observations used to initialize the forecast models in these regions. While sea surface temperature (SST) fields derived from satellite and in situ data currently provided to the models provide some large scale information on surface forcing, the small scale grad...

Octreotide is a somatostatin analogue that is widely used for cancer therapy and tumor imaging. Its efficacy in tumors depends mainly on the expression of the somatostatin receptor type 2 (sst 2). Desensitization and down-regulation of sst 2 after agonist exposure can have important consequences for patients under ongoing octreotide therapy because it may induce temporary tumor unresponsiveness...

The dominant pattern of tropical and subtropical North Atlantic sea surface temperature (SST) anomalies simulated in the GFDL coupled ocean-atmosphere model is identified and compared to observations. The spatial pattern and temporal variability of that pattern resemble observational results. On interannual time scales it is shown that anomalous surface heat fluxes, consistent with variations i...

[1] We use elemental ratio (Mg/Ca, Sr/Ca, U/Ca and Ba/Ca) and oxygen isotope data from a Porites lutea coral head collected from offshore Amédée Island, New Caledonia (22 290S, 166 280E) to assess the degree to which changes in these geochemical variables reflect variations in sea surface conditions. We have assessed the robustness of each geochemical proxy by comparing 25 years (1992–1968) of ...

Sea surface temperature (SST) is an important parameter used in many applications, such as fisheries, weather forecasting as boundary condition, and monitoring of climate changes. In these applications, SST is necessary under both fine and cloudy conditions, which can be made by passive microwave radiometers in particular under cloudy condition. To measure SST by microwave radiometers, frequenc...

Inhibitory circuitry plays an integral role in cortical network activity. The development of transgenic mouse lines targeting unique interneuron classes has significantly advanced our understanding of the functional roles of specific inhibitory circuits in neocortical sensory processing. In contrast, considerably less is known about the circuitry and function of interneuron classes in piriform ...