Studies have shown that the application of Self-Regulated Learning (SRL) increases the effectiveness of education. However, this is quite challenging to be facilitated with learning technologies like Learning Management Systems (LMS) that lack an individualised approach as well as a right balance between the learner’s freedom and guidance. Personalisation and adaptive technologies have a high p...

In a multicenter trial, renal transplant recipients were randomized to tacrolimus with fixed-dose sirolimus (Tac/SRL, N = 318) or tacrolimus with MMF (Tac/MMF, N = 316). Targeted tacrolimus trough levels were lower in the Tac/SRL group after day 14. The primary endpoint was renal function at 6 months using creatinine clearance (Cockcroft-Gault) and was comparable at 66.4 mL/min (SE 1.4) with Ta...

Some studies suggest that Sirolimus (SRL) is associated with an increased risk of death in liver transplant recipients compared to treatment with calcineurin inhibitors (CNIs). We compared patients who received SRL or CNI in the first year after liver transplant. Our database included 688 patients who received a liver transplant. The patients were divided into groups. (1) CNI + MPS (mycophenola...

Chronic allograft nephropathy (CAN) is a major cause of graft loss in long-term kidney transplant recipients. To identify the safety and efficacy of conversion from calcineurin inhibitors (CNI) to sirolimus (SRL) in patients with CAN, we investigated 92 biopsy demonstrated CAN patients during a 5-year follow-up.45 patients were converted to sirolimus treatment (SRL group) and remaining 47 patie...

As a critical language, there is huge potential for the usefulness of an Arabic Semantic Role Labeling (SRL) system. This task involves two subtasks: predicate argument boundary detection and argument classification. Based on the innovations of Diab, Moschitti, and Pighin (2007) in the field of Arabic Natural Language Processing (NLP), SRL in particular, we are currently developing a system for...

We introduce the SDIF Stream Relationships Language (“SDIF-SRL”), a formal language for describing the relationships among streams in an SDIF file. SDIF-SRL is based on XML, the “Extensible Markup Language,” an emerging standard for data modeling and representation. We describe the structure of SRL and its use in several applications.

OBJECTIVE Semantic role labeling (SRL), which extracts a shallow semantic relation representation from different surface textual forms of free text sentences, is important for understanding natural language. Few studies in SRL have been conducted in the medical domain, primarily due to lack of annotated clinical SRL corpora, which are time-consuming and costly to build. The goal of this study i...

BACKGROUND Stent-based delivery of sirolimus (SRL) has shown reduction in neointimal hyperplasia and restenosis. The purpose of this study was to evaluate the chronic vascular response and the expression of cell cycle regulators after SRL-eluting stent implantation in a porcine coronary model. METHODS Forty-nine pigs underwent placement of 109 oversized stents (control, n=54, SRL (140 microg/...

Enhancement of calcineurin inhibitor nephrotoxicity by sirolimus (SRL) is limiting the clinical use of this drug combination. We compared the dose-dependent effects of the structurally related everolimus (EVL) and sirolimus (SRL) alone, and in combination with cyclosporine (CsA), on the rat kidney. Lewis rats were treated by oral gavage for 28 days using a checkerboard dosing format (0, 3.0, 6....

BACKGROUND Anaemia and microcytosis are common post kidney transplantation. The aim of this study was to evaluate the potential role of mammalian target of rapamycin (mTOR) inhibition in the development of anaemia and microcytosis in healthy animals and in human erythroid cultures in vitro. METHODS Rats with normal kidney function were treated with sirolimus (n = 7) or vehicle (n = 8) for 15 ...