PURPOSE To determine the efficacy and safety of mitomycin-C as adjunctive treatment and to compare this drug with beta irradiation with strontium-90 after surgical excision of primary and recurrent pterygia. MATERIALS AND METHODS The study group consisted of 193 patients with primary and recurrent pterygia who underwent surgical excision with the bare sclera technique. They were divided into ...

Recent studies from our laboratory (Yancey, P.G., and R. W. St. Clair. 1992. Arterioscler. Thromb. 12: 1291-1304) have shown that cultured peritoneal macrophages from White Carneau (WC) pigeons clear cholesteryl esters at a slower rate than do macrophages from Show Racer (SR) pigeons (9% per 24 h vs. 42% per 24 h, respectively) when incubated in the presence of a cholesterol acceptor apo high d...

Ion gradients imposed across an internal membrane system stimulate skinned muscle fibers; to evaluate the sarcoplasmic reticulum (SR) as the primary target site, SR polarization under resting and stimulatory conditions was assessed from fiber uptake o f permeant probe ions. Solvent spaces were estimated from simultaneous [14C]urea (U) or [SH]deoxyglucose (DOG) uptake in segments o f fibers from...

BACKGROUND Delayed afterdepolarizations (DADs) carried by Na(+)-Ca(2+)-exchange current (I(NCX)) in response to sarcoplasmic reticulum (SR) Ca(2+) leak can promote atrial fibrillation (AF). The mechanisms leading to delayed afterdepolarizations in AF patients have not been defined. METHODS AND RESULTS Protein levels (Western blot), membrane currents and action potentials (patch clamp), and [C...

This study examines factors associated with activity limitation and the decline in quality of life patients knee osteoarthritis (OA), to determine standard values that would be useful for understanding disease state. We assessed individual factors, modified version Self-Rating Frenchay Activities Index (SR-FAI), Japanese Knee Osteoarthritis Measure (JKOM) 661 participants. Multiple regression a...

OBJECTIVE Prospective randomised study comparing patients with atrial fibrillation (AF) of more than 6 months duration after mitral valve surgery plus biatrial modified radiofrequency Maze procedure using Medtronic Cardioblate System (Cardioblate group, n=24) vs mitral valve surgery plus intensive rhythm control strategy (control group, n=25). METHODS Patients were blinded to randomisation. P...