Increased lipogenesis and protein synthesis is a hallmark of cancer cell proliferation, survival, and metastatic progression and is under intense investigation as a potential antineoplastic target. Acetyltanshinone IIA (ATA) is a compound that was obtained from chemical modifications of tanshinone IIA (TIIA), a potent anticancer agent extracted from the dried roots of the Chinese herbal medicin...

BACKGROUND Polycomb-group (PcG) and trithorax-group (trxG) proteins regulate histone methylation to establish repressive and active chromatin configurations at target loci, respectively. These chromatin configurations are passed on from mother to daughter cells, thereby causing heritable changes in gene expression. The activities of PcG and trxG proteins are regulated by a special class of prot...

Classical automated test assembly (ATA) methods assume fixed and known coefficients for the constraints objective function. This hypothesis is not true estimates of item response theory parameters, which are crucial elements in classical models. To account uncertainty ATA, we propose a chance-constrained version maximin ATA model, allows maximizing α-quantile sampling distribution information f...

Inequalities for convex functions on the lattice of partitions of a set partially ordered by refinement lead to multivariate generalizations of inequalities of Cauchy and Rogers-Hölder and to eigenvalue inequalities needed in the theory of population dynamics in Markovian environments: If A is an n× n nonnegative matrix, n > 1, D is an n× n diagonal matrix with positive diagonal elements, r(·) ...

SYDNEY, Australia, Thursday 30 March 2017: Uscom Limited (ASX code: UCM) (the Company or Uscom) announced the publication of two new peer reviewed papers confirming the effectiveness of USCOM 1A for diagnosing pre-eclampsia and guiding hypertensive therapy in pregnancy. The publications were in the prestigious Ultrasound in Obstetrics and Gynaecology and authored by obstetrics and gynaecology s...

Yersinia sp. bacteria owe their viability and pathogenic virulence to the YopH factor, which is a highly active bacterial protein tyrosine phosphatase. Inhibition of YopH phosphatase results in the lack of Yersinia sp. pathogenicity. We have previously described that aurintricarboxylic acid inhibits the activity of YopH at nanomolar concentrations and represents a unique mechanism of YopH inact...

BACKGROUND Remote patient monitoring is increasingly integrated into health care delivery to expand access and increase effectiveness. Automation can add efficiency to remote monitoring, but patient acceptance of automated tools is critical for success. From 2010 to 2013, the Diabetes-Depression Care-management Adoption Trial (DCAT)-a quasi-experimental comparative effectiveness research trial ...

INTRODUCTION After initial treatment, differentiated thyroid cancer (DTC) patients are stratified as low and high risk based on clinical/pathological features. Recently, a risk stratification based on additional clinical data accumulated during follow-up has been proposed. OBJECTIVE To evaluate the predictive value of delayed risk stratification (DRS) obtained at the time of the first diagnos...