Cortical spreading depression and depolarization (CSD) are waves of neuronal that spread across the cortex, leading to a temporary saturation brain activity. They associated with various disorders such as migraine ischemia. We consider reduced version biophysical model neuron–astrocyte network for initiation propagation CSD [Huguet et al., Biophys. J. 111(2), 452–462, 2016], consisting reaction...

More than 50% of total energy consumed by the brain is utilized active transport processes which are responsible for keeping ionic homeostasis in brain. Under an ischemic condition, availability limited, and, as a result, inhibition ion pumps unavoidable. The initial consequence such gradual accumulation K+ extracellular space leading to second phase depolarization phenomenon. During depolariza...

BACKGROUND AND PURPOSE Clinical and experimental evidence suggests that spreading depolarization facilitates neuronal injury when its duration exceeds a certain time point, termed commitment point. We here investigated whether this commitment point is shifted to an earlier period, when spreading depolarization is accompanied by a perfusion deficit. METHODS Electrophysiological and cerebral bl...

introduction: a close link between spreading depression (sd) and several neurological diseases such as epilepsy could be demonstrated in many experimental studies. epilepsy is among the most common brain disorders. despite a large number of investigations, its mechanisms have not been yet well elucidated. hippocampus is one of the important structures involved in seizures. the aim of this study...

BACKGROUND AND PURPOSE Sustained mass depolarization of neurons, termed cortical spreading depolarization, is one electrophysiological correlate of the ischemic injury of neurons. Cortical spreading depolarizations spread in the gray matter at a rate of approximately 3 mm/min and are associated with large infraslow extracellular potential changes (<0.05 Hz). Moreover, smaller infraslow potentia...