Future high resolution instruments planned by CNES to succeed SPOT5 will lead to higher bit rates because of the increase in both resolution and number of bits per pixel, not compensated by the reduced swath. Data compression is then needed, with compression ratio goals higher than the 2.81 SPOT5 value obtained with a JPEG like algorithm. Compression ratio should rise typically to 4-6 values, w...

Nordqvist, S. 2014. Biological Markers of Fertility. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1048. 74 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9085-0. Infertility affects 15 % of couples, which corresponds to 60 80 million worldwide. The microenvironments in which the oocyte, embryo and fetus mature are vital to the establishment...

Traditional change detection approaches have been proven to be difficult in detecting vegetation changes in the moist tropical regions with multitemporal images. This paper explores the integration of Landsat Thematic Mapper (TM) and SPOT High Resolution Geometric (HRG) instrument data for vegetation change detection in the Brazilian Amazon. A principal component analysis was used to integrate ...

Signal transduction and cell responses after stimulation with heregulin β-1 (HRG) are examined in HCC2998 and MKN45-1 cells, which have been used for a model system to study the formation of signet ring carcinomas, one of poorly differentiated adenocarcinomas. HRG stimulation causes rounding of the cells, responding to HRG. The adherens junction, which is present in the control cells, is disrup...

Resistance of breast carcinomas to hormonal therapy is a clinical obstacle for the treatment of breast cancer. The molecular mechanisms and the factors involved in the progression of tumors from an estrogen (E2)-dependent to an E2-independent phenotype are not entirely understood. Heregulin (HRG) is a pleiotropic growth factor that binds to the erbB family of receptors, which are correlated wit...

Growth factor receptors provide unique opportunities for development of targeted anticancer therapy. Members of the type I receptor tyrosine kinase family, including epidermal growth factor (EGF) receptor (EGFR) and ErbB-2/neu, are often overexpressed in various human cancer cells, including breast. Recently, it has been shown that both ErbB-3 and ErbB-4 are receptors for heregulin (HRG)/Neu di...

BACKGROUND During early clinical development, prospective identification of a predictive biomarker and validation of an assay method may not always be feasible. Dichotomizing a continuous biomarker measure to classify responders also leads to challenges. We present a case study of a prospective-retrospective approach for a continuous biomarker identified after patient enrollment but defined pro...

Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of malignancy, but their molecular basis and interrelationship remains enigmatic. We report that the host-produced histidine-rich glycoprotein (HRG) inhibits tumor growth and metastasis, while improving chemotherapy. By skewing TAM polari...

HER3 (also known as c-Erb-b3) is a type I receptor tyrosine kinase similar in sequence to the epidermal growth factor (EGF) receptor. The extracellular segment of this transmembrane receptor contains four domains. Domains I and II are similar in sequence to domains III and IV, respectively, and domains II and IV are cysteine-rich. We show that the EGF-like domain of heregulin (hrg) binds to dom...

OBJECTIVE To report an unusual case of oral hyaline ring granuloma (HRG) that caused an extensive osteolytic lesion. CLINICAL PRESENTATION AND INTERVENTION A 22-year-old female was referred to our hospital with a large expansile cystic lesion in the left mandibular ramus associated with a clinically visible, partially erupted third molar. A diagnosis of paradental cyst was made. After marsupi...