larsen syndrome is a skeletal dysplasia (osteochondro-dysplasia) in which multiple dislocations of the large joints are the major feature . nosology in this group of disease, which constitutes 8% of mendelian disorders in man, is primarily based on clinical and radiological features. the underlying genetic defect is 3p21.1-p14.1 in the dominant type

  A 29- year old female with bone pain and history of precocious puberty was referred for bone scintigraphy. On physical examination café au lait macular spots were noted on her neck, buttocks and left leg. Bone scan showed multiple areas of intense increased activity which was in favour of polyostotic fibrous dysplasia. Considering the presence of polyostotic fibrous...

Leukoplakias (LPLs) are lesions in the oral mucosa that may develop into oral squamous cell carcinoma (OSCC). The objective of this study was to assess presence and distribution of dendritic Langerhans cells (LCs) and T cells in patients with LPLs with or without cell dysplasia and in oral squamous cell carcinoma (OSCC). Biopsy specimens from patients with leukoplakias (LPLs) with or without dy...

OBJECTIVES Recurrent respiratory papillomatosis (RRP) is often described as a benign disease. However, the natural progression of dysplasia and transformation to squamous cell carcinoma has not been elucidated for RRP. This study delineates our extensive experience with dysplasia in RRP. STUDY DESIGN/SETTING Case series with chart review. SUBJECTS AND METHODS Demographic data and surgical p...

Among oral lesions, we encounter a series of malignant epithelial lesions that go through clinical and histopathologic processes in order to be diagnosed. Identifying these processes along with the etiology knowledge of these lesions is very important in prevention and early treatments. Dysplasia is the step preceding the formation of squamous cell carcinoma in lesions which have the potential ...

conclusion various filters are needed to improve the image quality. in this study, seven different filters were implemented and investigated on both noisy and noise-free images. background developmental dysplasia of the hip (ddh) can be detected with ultrasonography (usg) images. however, the accuracy of this method is dependent on the skill of the radiologist. radiologists measure the hip join...

objectives: ectrodactyly-ectodermal dysplasia-clefting syndrome (eec) is a rare syndrome with features of ectrodactyly, ectodermal dysplasia and cleft lip/palate. this study presents an iranian case with classic features and oral complications.   case: we report a 20-year old female with all manifestations of this syndrome. the simultaneous presence of these three malformations is extremely rar...

Esophageal cancer remains a highly lethal malignancy for which the genetic and proteomic events are poorly understood. Studies have reported dysregulated proteins in esophageal carcinoma; however, the magnitude of these changes remains largely uncharacterized. Little is known about alterations early in the neoplastic pathway. Using multiplex tissue immunoblotting, we quantified the expression o...

Esophageal cancer remains a highly lethal malignancy for which the genetic and proteomic events are poorly understood. Studies have reported dysregulated proteins in esophageal carcinoma; however, the magnitude of these changes remains largely uncharacterized. Little is known about alterations early in the neoplastic pathway. Using multiplex tissue immunoblotting, we quantified the expression o...

Objectives: E-cadherin is a transmembrane glycoprotein, which is responsible for cell adhesion and its expression decreases in dysplastic lesions. This study aimed to assess the expression of this marker in oral lichen planus (OLP) with and without dysplasia to assess its potential for use as a predictor of malignant transformation. Methods: This descriptive, cross-sectional study w...