membrane permeability and p-glycoprotein (p-gp) efflux system are regulating factors in the drug brain penetration. recently, some drug delivery systems have been developed to overcome these limitations. in this study, metoclopramid has been encapsulated in plga nanoparticles using the emulsification/solvent evaporation technique for in vitro evaluation of the effect of plga nanoparticles on bb...

Objective(s): Nanoparticles offer an attractive platform for drug delivery through a wide variety of the body's physiological barriers. Furthermore, modification of nanoparticle surface with moeites such as Poloxamer188 can enhance their accumulation and localization at disease site. In this work, we investigated the physiochemical effect of a scavenger receptor (SR-BI) interac...

This study proposes a new concept of pH-sensitive poly(lactide-co-glycolide) (PLGA) nanoparticle composite microcapsules for oral delivery of insulin. Firstly, insulin-sodium oleate complex was prepared by the hydrophobic ion pairing method and then encapsulated into PLGA nanoparticles by the emulsion solvent diffusion method. In order to reduce the burst release of insulin from PLGA nanopartic...

Superparamagnetic iron oxide nanoparticles (SPION), as magnetic resonance (MR) imaging contrast agents or magnetic targeting carriers, have potential applications in diagnostics, imaging, cell and drug/ gene delivery for cardiovascular diseases. SPION are highly magnetic particles that cause magnetic field perturbations, which can be identified on T2* weighted images [1]. Clinically, SPION allo...

In the present study, a targetable vector was developed for the targeted delivery of anticancer agents, consisting of lipid-coated poly D,L-lactic-co-glycolic acid nanoparticles (PLGA-NP) that were modified with transferrin (TF). Doxorubicin (DOX) was used as a model drug for lung cancer therapy. The use of these NPs combined the advantages and avoided the disadvantages exhibited individually b...

background: disulfiram is oral aldehyde dehydrogenase (aldh) inhibitor that has been used in the treatment of alcoholism. recent studies show that this drug has anticancer properties; however, its rapid degradation has limited its clinical application. encapsulation of disulfiram polymeric nanoparticles (nps) may improve its anticancer activities and protect rapid degradation of the drug. mater...

Intraperitoneal cisplatin delivery has recently been shown to benefit ovarian cancer patients. Cisplatin-containing poly(lactide-co-glycolide) (PLGA) microspheres have been proposed for cisplatin delivery. The drug loading of cisplatin containing microspheres produced elsewhere is 3-10 %w. Similar microspheres are reported here with a mean diameter of 38.8 μm, and a drug loading of 11.7 %w, but...

the objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (dds) for metoprolol tartarate (mt) as tablet and capsule. pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery ...

Porous ceramic microspheres are a desirable substance for bone tissue reconstruction and delivery applications. This study focuses on Mg–Ca silicate encapsulated in biodegradable poly (lactic-co-glycolic acid) (PLGA) to serve as biocompatible carrier the controlled release of vancomycin hydrochloride. In this regard, diopside (MgCaSi 2 O 6 ), bredigite (MgCa 7 Si 4 16 akermanite ) powders were ...

Poly (D,L-lactide-co-glycolic acid) the first synthetic biodegradable polymer used in surgery as resorbabe material, is also approved by USFDA for use in drug delivery. The nanoparticle composed of PLGA can be used for both controlled and targeted drug delivery. There are various grades of PLGA which are having different biodegradation characteristics such as degradation takes place in several ...