cortical spreading depression (csd) has been suggested to underlie some neurological disorders such as migraine. despite the intensity with which many investigators have studied sd in the brain, only a few studies have aimed to identify sd in the spinal cord. here we described the main characteristic features of sd in the spinal cord induced by different methods including various spinal cord in...

Sustained administration of opioid antagonists to rodents results in an enhanced antinociceptive response to agonists. We investigated the changes in spinal μ-opioid receptor signalling underlying this phenomenon. Rats received naltrexone (120 μg/h; 7 days) via osmotic minipumps. The antinociceptive response to the μ-agonist sufentanil was tested 24 h after naltrexone withdrawal. In spinal cord...

Abstract Background Patients with spinal muscular atrophy (SMA) are at risk of decreased bone mineral density (BMD). The health status Chinese patients SMA has been poorly studied. We aimed to evaluate the BMD children types 2 and 3 in mainland China investigate its influencing factors. Methods Forty a mean age 5.5 years affected by ( n = 22 18, respectively) were enrolled between September 201...

Several extracellular matrix (ECM) molecules have been identified as potent inhibitors of neurite outgrowth in vitro and are believed to limit axonal growth after CNS injury. Recent studies have shown that different members of the chondroitin sulfate proteoglycan (CSPG) class of putatively inhibitory ECM molecules are expressed after a number of CNS injuries. The purpose of this study was to ev...

In vivo imaging using two-photon microscopy in mice that have been genetically engineered to express fluorescent proteins in specific cell types has significantly broadened our knowledge of physiological and pathological processes in numerous tissues in vivo. In studies of the central nervous system (CNS), there has been a broad application of in vivo imaging in the brain, which has produced a ...

We performed genetic mapping studies of an 11-generation pedigree with an autosomal dominant, juvenile-onset motor-systems disease. The disorder is characterized by slow progression, distal limb amyotrophy, and pyramidal tract signs associated with severe loss of motor neurons in the brain stem and spinal cord. The gene for this disorder, classified as a form of juvenile amyotrophic lateral scl...

Recently we have reformulated the octonions as quasissociative algebras (quasialgebras) living in a symmetric monoidal category. In this note we provide further examples of quasialgebras, namely ones where the nonassociativity is induced by a Z Z n-grading and a nontrivial 3-cocycle.

results the rate of first-time successful spinal needle insertion was not significantly different between the clsp and tsp groups (62.9% versus 55.7%, p > 0.05). ease of landmark palpation in the clsp group was not significantly different from that in the tsp group (86.7% versus 76.4%, p > 0.05). the number of needle-bone contacts in both groups were not significantly different (p > 0.05). the ...

this study was conducted to evaluate the effects of maternal diabetes on fetal spinal structure, especiallyin brachial enlargement. sixteen adult female rats were divided into two groups. diabetes was induced in one group by alloxan agent. both groups became pregnant by natural matting. on days 7, 14, 21 and 28 after birth, the brachial enlargement of the spinal cord was collected from offsprin...

With the addition of IBM System ze application assist processors (zAAPs) and integrated information processors (zIIPs) to the portfolio of special-purpose IBM System z processors, the reinvention of the IBM mainframe continues. Jointly, zAAPs and zIIPs provide significant IBM System z9e integrated and cost-effective processing cycles for today’s strategic Javae and DB2t for z/OSt programming pl...