Background :Cell-based therapies can be used to treat neurological diseases and spinal cord injuries. The aim of this study was to assess the clinical outcome of bone marrow derived mononuclear cells (BM-MNCs) transplantation in patients with spinal cord injuries.   Method s: Following a systematic review to detect clinical intervention studies, a meta-analysis was done for pooling data to es...

STUDY DESIGN A retrospective review was performed to identify patients at risk for secondary neurologic deterioration after complete cervical spinal cord injury. OBJECTIVE To examine the causes of early neurologic deterioration in patients with complete spinal cord injury at a regional spinal cord injury center. SUMMARY OF BACKGROUND DATA After complete spinal cord injury, neurologic deteri...

objective: because of the necessity of more effective treatments for the nervous system injuries and considering the role of survivin in cellular proliferation and apoptotic cell death, we have monitored survivin gene expression changes during the course of regeneration in injured sciatic nerves and also l4-l6 segments of spinal cord. materials and methods: we used adult male nmri mice as a mo...

One strategy for spinal cord injury repair is to make cellular bridges that support axon regeneration. However, the bridging cells often fail to integrate with host tissue and may lead to increased pain sensitivity. Recent work has tested bridging with two forms of progenitor-derived astrocyte. One type integrates, suppresses scar formation and promotes axon regeneration, whereas another very s...

Unlike those in the periphery, nerve fibers in the central nervous system (brain and spinal cord) do not recover from traumatic injury. This makes disabilities from spinal cord damage permanent, with the severity depending on the location of the cord injury. Neck injuries can paralyze the torso and limbs, while lower back injuries can impair movement below the waist. The spinal cord is a bundle...

We conducted a retrospective study in which we related the outcome of spinal cord injury to the presence of serious accompanying injuries. From 1974 through 1979, 144 patients with spinal cord trauma were admitted to the Acute Spinal Cord Injury Unit of Sunnybrook Medical Centre, 27 (19%) of whom had other major injuries of Grade 3 or higher according to the Abbreviated Injury Scale. These addi...

A spinal cord injury (SCI) refers to any injury to the spinal cord that is caused by trauma instead of disease. Depending on where the spinal cord and nerve roots are damaged, the symptoms can vary widely, from pain to paralysis to incontinence. Spinal cord injuries are described at various levels of "incomplete", which can vary from having no effect on the patient to a "complete" injury which ...

Litigating a spinal cord injury case can be extremely complex and challenging because your client has suffered a devastating injury with lifelong complications. However, these cases can be extremely rewarding. A successful resolution by settlement or jury verdict can provide your client and his dependent family members with a lifetime of financial security. To properly represent your client, yo...