BACKGROUND Acrylamide (AA) is an important industrial chemical primarily. AA is also found in carbohydrate-rich foods that are prepared at high temperatures, such as French fries and potato chips. It is demonstrated that AA is a carcinogen and reproductive toxin and has ability to induce sperm damage. OBJECTIVE The aim of this study was to observe the effects of AA on sperm parameters and eva...

Data obtained by the sperm chromatin structure assay (SCSA) on spermatozoa from nine bulls were correlated with fertility, measured by heterospermic performance (-0.94, P less than 0.01) and by alternate tests of sperm quality, including motility, acrosome integrity, Sephadex filtration and morphology of spermatozoa (all significant at P less than 0.05 to P less than 0.01). The SCSA uses flow c...

BACKGROUND Currently, relation between reactive oxygen species (ROS) ROS concentration and semen quality was indicated. Saffron has traditionally been not only considered as a food additive but also as a medicinal herb, which has a good antioxidant properties. OBJECTIVE The aim of this study was to evaluate the protection potency of saffron and vitamin E on sperm chromatin integrity. MATERI...

introduction: different methods have been used to evaluate the beneficial effect of varicocelectomy; these include semen parameters and pregnancy rate. due to high biological variability of semen parameters, sperm functional test has been considered an efficient end point in assessment of fertility. therefore, the aim of this study was to evaluate the effect of varicocelectomy on semen paramete...

BACKGROUND Exposures to lead above the threshold value of 50-60 μg/dL have been linked to diminished semen quality parameters. Worldwide, the lead exposure has been diminished during the last years. Therefore, it has become of a great concern to examine the effects of lead exposures on semen quality at low levels of exposure. OBJECTIVE To evaluate the effect of low level (<20 μg/dL) blood lea...

(Abstracted from Hum Reprod 2022;37:1106–1125) With intracytoplasmic sperm injection (ICSI), many natural barriers that would normally prevent the entry of abnormal are lost, increasing importance DNA integrity for successful in vitro fertilization. There is currently no consensus on optimal assay measuring quality (DNAq), defined as any structural aspect chromatin can compromise function if di...

A significant association between male subfertility, imperfect spermiation and abnormal nuclear condensation has been suggested. The DNA content of spermatozoa might be responsible for inducing alterations in sperm morphology. The final nuclear shape, which is species-specific, depends on chromatin condensation during spermatogenesis as well as a precise organization of DNA within the nucleus. ...

The process of sperm chromatin decondensation occurs when a spermatozoon enters an ovum. Protamine disulphide bonds are reduced to SH and the polycationic protamines combine with the polyanionic egg protein, nucleoplasmin, thus being stripped from DNA which then combines with histones. Defective chromatin decondensation will thus prevent further development of the male pronucleus. In this study...