Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by pulmonary vascular remodeling. Immunoglobulin E (IgE) known to participate in aortic remodeling, but whether IgE mediates unknown. In the present study, we found serum elevation arterial (PAH) patients, hypoxia-induced PH mice and monocrotaline-induced rats. Neutralizing with an anti-IgE antibody was effective prev...

cow’s  milk  anaphylaxis is  the  most  common  food-induced  anaphylaxis in  iranian children. the clinical and laboratory findings of cow’s milk anaphylaxis are evaluated in this study. all children who had experienced cow’s  milk anaphylaxis and had been referred to immunology, asthma and allergy research center during a 5-year period were considered. after fulfilling a questionnaire, patien...

Total serum IgE is associated with asthma independently of specific IgE levels. J. Sunyer, J.M. Antó, J. Castellsagué, J.B. Soriano, J. Roca, and the Spanish Group of the European Study of Asthma. ©ERS Journals Ltd 1996. ABSTRACT: In this study we aimed to assess whether the association between asthma (defined by symptoms and bronchial responsiveness) and total immunoglobulin E (IgE) levels was...

BACKGROUND Naturally occurring IgE-specific IgG autoantibodies have been identified in patients with asthma and other diseases, but their spectrum of functions is poorly understood. OBJECTIVE Address the hypothesis that: (i) IgG anti-IgE autoantibodies are detectable in the serum of all subjects but elevated in asthmatic patients regardless of atopic status as compared with controls; (ii) som...

We studied Hymenoptera stings in 72 pest-control operators without any previous systemic reactions to Hymenoptera stings, and investigated their venom-specific IgE levels in serial specimens collected over one year. At the initial evaluation, venom-specific IgE was present in 25 (34.7%) of 72 pest-control operators, and venom-specific IgE titer significantly decreased as the time interval from ...

Background: Allergens are mostly composed of glycoprotein structures. It is believed that glycan-specific antibodies may lead to false-positive reactions in immunoassays. In this study we investigated the glycosylation state of grape allergens as well as the presence of antibodies to cross-reactive carbohydrate determinants (anti-CCDs) in sera from grape-sensitive individuals. Methods: Grape...

IgE antigen complexes induce increased specific T cell proliferation and increased specific IgG production. Immediately after immunization, CD23(+) B cells capture IgE antigen complexes, transport them to the spleen where, via unknown mechanisms, dendritic cells capture the antigen and present it to T cells. CD23, the low affinity IgE receptor, binds IgE antigen complexes and internalizes them....

BACKGROUND Total IgE levels in allergic patients tend to be higher than those in healthy individuals. We evaluated the usefulness of total IgE levels in predicting positive results of allergen specific IgEs in multiple allergen simultaneous tests. METHODS A total of 133 patients with allergic symptoms were evaluated. Allergen specific IgEs were detected using 3 different kits: Allergy screen ...

Cow’s milk allergy (CMA) is one of the most common food allergies in first years life. CMA classified as immunoglobulin E (IgE)or non-IgE-mediated reactions. IgE-mediated reactions are typically immediate onset, with symptoms manifesting within 2 hours after ingestion. However, delayed and mostly occur between 48 post exposure. This report describes a 17-year-old who presented long-standing his...