Software systems are complex, as they must cover a diverse set of requirements describing functionality and the environment. Software engineering addresses this complexity with Model-Driven Engineering (MDE). MDE utilizes different models and metamodels to specify views and aspects of a software system. Subsequently, these models must be transformed into code and other artifacts, which is perfo...

We examined the changes that arise when neurotransmitter release is inhibited in a subpopulation of hippocampal neurons in coculture with normally active neighbors. Subsets of neurons were presynaptically silenced by chronic expression of tetanus toxin light chain tagged with cyan fluorescent protein (TNTCFP). Surprisingly, silenced neurons formed as many presynaptic terminals as their active n...

Although hematophagous black flies are well-known socioeconomic pests and vectors of disease agents, their associated bacteria are poorly known. A systematic analysis of the bacterial community associated with freshly emerged adult black flies of four North American species, using cultivation-independent molecular techniques, revealed 75 nonsingleton bacterial phylotypes. Although 17 cosmopolit...

Both model-driven architecture MDA and aspectoriented programming AOP are promising paradigms that are very attractive for the software engineering community. While the former is an approach to application design and implementation using models as first class entities, the latter advocates the separation of concerns as an approach to tackle most software development and maintenance problems. MD...

Large numbers of tumor associated antigens has been characterized, but only a minor fraction of these are recognized by tumor infiltrating lymphocytes of melanoma, although these have shown the ability to recognize tumor and provide tumor regression upon adoptive transfer. Thus the peptide recognition of the majority of the CD8 tumor infiltrating lymphocytes remains to be identified.