Dendritic cells (DCs) are antigen presenting cells with unique capability to take up and process antigens in the peripheral blood and tissues. They subsequently migrate to draining lymph nodes where they present these antigens and stimulate naive T lympho-cytes. During their life cycle, DCs go through two maturation stages and are referred to as immature and mature cells, respectively. While im...

BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific ("idiotypic") determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 grew in several of the mice immunized with this protein, probably because the a...

anisms of the animals in which the neoplasms originate. Al most all of the putatively nonviral tumors are individually specific and few, if any, cross-reactions occur among them. The antigenic titer varies greatly and is related to the latent period and the immunologie reactivity of the tumor host. This rela tionship is almost certainly due to immunoselection. The an tigens are found in early p...

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INTRODUCTION Four years have passed since the last comprehensive meeting was held to discuss directions in which the immunological discipline might contribute to an understanding of cancer problems, and it should be a measure of our progress to compare the content of the papers presented at that meeting with those delivered here. The earlier meeting did not have precisely the same objectives as...