Recently solved outer membrane protein structures include the smallest and largest known beta-barrel structures, with functions distinct from the general and specific porins. Both protein expressed in outer membranes and protein deposited as cytoplasmic aggregates have been used for the structure determinations. As most beta-barrel proteins can be overexpressed in an aggregated form (inclusion ...

The amino acid composition and architecture of all -barrel membrane proteins of known three-dimensional structure have been examined to generate information that will be useful in identifying -barrels in genome databases. The database consists of 15 nonredundant structures, including several novel, recent structures. Known structures include monomeric, dimeric, and trimeric -barrels with betwee...

Vaults are ribonucleoprotein particles with a distinct structure and a high degree of conservation between species. Although no function has been assigned to the complex yet, there is some evidence for a role of vaults in multidrug resistance. To confirm a direct relation between vaults and multidrug resistance, and to investigate other possible functions of vaults, we have generated a major va...

Vaults are ribonucleoprotein particles with a distinct structure and a high degree of conservation between species. Although no function has been assigned to the complex yet, there is some evidence for a role of vaults in multidrug resistance. To confirm a direct relation between vaults and multidrug resistance, and to investigate other possible functions of vaults, we have generated a major va...

Terrestrial laser-scanning (TLS) is well suited to surveying the geometry of monumental complexes, often realised with highly irregular materials and forms. This paper addresses various issues related acquisition point clouds via TLS their elaboration aimed at developing structural models masonry vaults. system, which exists in numerous artifacts historical buildings, has advantages good static...

The outer membrane protein OprM of Pseudomonas aeruginosa is involved in intrinsic and mutational multiple-antibiotic resistance as part of two resistance-nodulation-division efflux systems. The crystal structure of TolC, a homologous protein in Escherichia coli, was recently published (V. Koronakis, A. Sharff, E. Koronakis, B. Luisl, and C. Hughes, Nature 405:914-919, 2000), demonstrating a di...

The seismic analysis of historical and monumental masonry buildings, especially churches cathedrals, is challenging expensive. These difficulties are mainly related to complex geometry the mechanical modelling historic structures. This paper aims show methodological approach evaluate vulnerability Masonry Cathedrals by analysis. numerical finite element model, modelled with solid elements, was ...

for the analysis of structures, the first step consists of configuration processing followed by data generation. this step is the most time consuming part of the analysis for large-scale structures. in this paper new graph products called triangular and circular graph products are developed for the formation of the space structures. the graph products are extensively used in graph theory and co...

Vault is the largest nonicosahedral cytosolic nucleoprotein particle ever described. The widespread presence and evolutionary conservation of vaults suggest important biologic roles, although their functions have not been fully elucidated. X-ray structure of vault from rat liver was determined at 3.5 Å resolution. It exhibits an ovoid shape with a size of 40 × 40 × 67 nm(3). The cage structure ...