The development of extracellular vesicles (EV) for therapeutic applications is contingent upon the establishment of reproducible, scalable, and high-throughput methods for the production and purification of clinical grade EV. Methods including ultracentrifugation (U/C), ultrafiltration, immunoprecipitation, and size-exclusion chromatography (SEC) have been employed to isolate EV, each facing li...

cohesive sediment transport remains a complicated subject that hydraulic engineers are frequently faced with in water-related engineering problems. this is primarily affected by the macroscopic aspects of water-sediment system characteristics. in this paper a 1-d mathematical model was developed to be employed in predicting the cohesive sediment transport under simultaneous conditions of erosio...

Objective: In this study, we aimed to investigate the incidence of cerebral desaturation and possible relationship between intraoperative postoperative complications. Methods: A prospective, observational study was performed 115 patients under 18 years age who required open heart surgery in a university hospital. Cerebral defined as 25% decrease saturation (low alarm limit) when compared with b...

Here we show more quantitive and qualitative results for region-based semantic flow and dense flow field. We first give quantitive comparisons with our PF benchmark in Sec. 1. We then compare quantitatively the performance of dense flow field on the PASCAL parts dataset [1, 14, 15] in Sec. 2. Finally, we show alignment examples of dense flow field on the PF benchmark, Caltech-101 [4], and PASCA...

A thermal stimulation system is described which is suitable for use in psychophysical, behavioral and neurophysiological studies of temperature sensation. Skin temperature over a restricted area can be maintained at temperatures of 30 to 60 degrees C. Heating from this initial temperature can be achieved at rates from 1.0 degrees C to 30 degrees C/second, up to a maximum temperature of 70 degre...

BACKGROUND Predischarge defibrillation threshold testing is often performed a few days after ICD implantation in order to validate defibrillation thresholds obtained at the time of implant. Ventricular fibrillation is induced with such testing and causes an increase in serum Brain Natriuretic Peptide (BNP) levels. BNP is an indicator for cardiac stress. We wanted to examine the feasibility to a...

In April 1999 the transient low mass X-ray binary X1658−298 resumed its strong and persistent X-ray emission after a 21-year interval of quiescence. We present RXTE data obtained soon after the reappearance, including four eclipses with a mean duration of 901.9±0.8 sec and ingress/egress times of 6–13 sec. Our updated ephemeris for the source indicates that the 7.1-hr orbital period of the syst...