The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR), ultraviolet, differential scanning calor...

The chemometric calibration performance was systematically investigated by two parameters (changing the chemical matrix as well as the signal-to-noise ratio) of the NIR (near-infrared) spectrum. Three different analytes (hexane, cyclohexane, toluene) were selected and heptane was used as a solvent. The degree of spectral difference significantly affected the calibration performance. The largest...

The three-dimensional “reference interaction site model” (3D-RISM) integral equation theory is a statisticalmechanical approach to predict liquid state structural and thermodynamic features. It is based on approximate solute-solvent correlation functions to be computed on a 3D grid as a function of the interaction potential between the solute and the solvent sites, circumventing the need of cos...

BACKGROUND Phthalates are synthetic compounds with a widespread field of applications. For example, they are used as plasticizers in PVC plastics and food packaging, or are added to personal care products. Diethyl phthalate (DEP) may be used to denature alcohol, e.g., for cosmetic purposes. Public health concerns of phthalates include carcinogenic, teratogenic, hepatotoxic and endocrine effects...

Pomegranate seed oil was extracted in a closed-vessel high-pressure microwave system. The characteristics of the obtained oil, such as fatty acid composition, free fatty acidity, total phenolic content, antioxidant activity and colour, were compared to those of the oil obtained by cold solvent extraction. Response surface methodology was applied to optimise extraction conditions: power (176-300...

The purpose of this research work was to obtain directly compressible enteric recrystallized agglomerates of erythromycin containing enteric polymers by emulsion solvent diffusion technique. Selected solvent for the process includes the best solvent (ethyl alcohol), non-solvent (distilled water) and bridging liquid (chloroform) according to their solubility in different organic solvent. The dif...

Problem statement: Jatropha curcas is a wonder plant with a variety of applications and enormous economic potentials. Oil from the seeds can be used as alternative fuel and for making biodiesel which aims to overcome energy crisis problems. In this study, extraction of Jatropha oil from seeds was optimized using organic solvent based on the amount of the extracted oil. The kinetics of extractio...

ABSTRACT
 Objective: In this study, it was aimed to prepare nanosuspensions that contains Indomethacin which is a BCS class II drug. To assess the cumulative impact of chosen variables on nanosuspension properties, 34 factorial design applied and particle size distributions were examined.
 Material Method: solvent/antisolvent method used in preparation suspensions. design. Design-Expe...