Sporadic nontoxic goiter (SNG) is defined as a benign enlargement of the thyroid gland in a euthyroid subject living in an iodine-sufficient area. Such goiters can be diffuse, uninodular, or multinodular and can vary greatly in size at presentation, growth rate, and symptomatology. The causes of SNG are incompletely understood, but include autoimmune, genetic, and extrinsic factors. SNG is a co...

Management of solitary thyroid nodule (STN) still remains uncertain despite the many sophisticated investigations which are presently available.l f The problem is aggravated by the fact, that in the literature, the quoted incidence of malignancy in STN varies depending on the basis of selection of cases for surgery, population studied, goitrogenicity of the region and the investigations used.l ...

Background. Pemphigus vulgaris is an autoimmune vesiculobullous disease, affecting the skin and mucous membranes. It is reported to be associated with other autoimmune diseases including autoimmune thyroid diseases. However we report herein a case of pemphigus vulgaris associated with autonomous toxic nodule. Case Presentation. A 51-year-old woman was evaluated for blisters and erosions that de...

BACKGROUND FNA biopsy of thyroid is a rapid, minimally invasive, and cost effective first line procedure in the evaluation of thyroid nodule. This study was conducted to evaluate the cytological accuracy, sensitivity and specificity of fine needle aspiration (FNA) of solitary thyroid nodules in correlation with post-surgical histological findings. METHODS This retrospective study was carried ...

BACKGROUND/AIM According to the current principles, autonomous functional thyroid nodules are treated by surgery or by radioiodin therapy. Ultrasound guided percutaneous ethanol injection into solid tumors of the soft tissues was a starting point in attempts to treat the thyroid nodules by the same method. The aim of the study was to assess the efficiency of percutaneous injection in treating s...

Thyroid nodules are common, with up to 8% of the adult population having palpable nodules. With the use of ultrasound, up to 10 times more nodules are likely to be detected. Increasing numbers of nodules are being detected serendipitously because of the rising use of imaging to investigate unrelated conditions. The primary aim in investigating a thyroid nodule is to exclude the possibility of m...

The efficacy of suppressing TSH secretion with levothyroxine (L-T(4)) in reducing solitary thyroid nodule growth is still controversial. In this prospective multicenter, randomized, double-blind, placebo-controlled trial, 123 patients with a single palpable benign nodule were included and randomly allocated to an 18-month treatment with L-T(4) or placebo. Individual dose was adjusted to allow a...