Objective: The study aimed to solubilization of imidazole drugs of interest; ketoconazole (KT) and miconazole nitrate (MN), for enhancement of the water solubility, the dissolution properties and the antimycotic activity of these drugs. Method: Different solid dispersion methods were used to prepare various dispersion systems of KT and MN using polyethylene glycol 4000 (PEG 4000), polyethylene ...

The aim of this study was to prepare solid dispersions of chlordiazepoxide techniques to improve its dissolution rate. To this end, three techniques namely, two solvent methods and co-grinding technique were used. Solid dispersions of chlordiazepoxide in polyvinylpyrrolidone (PVP), Eudragit E100, Mannitol and Sorbitol with two different ratios of drug to carrier (5:5 and 1:9) were prepared. The...

The oral Bioavailability of BCS (Bio Pharmaceutical Classification System) class II drug with poor solubility and reasonable permeability is limited by drug dissolution. The purpose of this research was to obtain enhancement of the dissolution profile of Mefenamic acid (MA) using solid dispersion technique with hydrophilic polymers such as poly ethylene glycol (PEG), polyvinyl pyrrolidone (PVP)...

OBJECTIVES Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). MATERIALS AND METHODS Solid dispersions of CLX:PVP or CLX:PLX were prepared at different ra...

Isolated from Annona squamosa L, Annonaceous acetogenins (ACGs) exhibit a broad range of biological properties yet absorbed badly due to the low solubility. Solid dispersion in polyethylene glycol 4000 (PEG 4000) has been developed to increase the solubility and oral absorption of ACGs. The formulation of ACGS-solid dispersion was optimized by a simplex lattice experiment design and carried out...

Flurbiprofen is a water insoluble non-steroidal anti inflammatory drug and belongs to BCS Class II categories. Solid dispersion is a technique by which we can improve it water solubility. By the help of fast dissolving formulation we can evaluate the effectiveness of solid dispersion. In this research work the solid dispersion of flurbiprofen with polymer like PVP K25, PVP K30, PVP K29-32, and ...

Poorly solubility in water of many newly developed high-potential drugs is an obstacle in formulation development. The aim of this study was to increase the solubility of Lamotrigine which is a poorly soluble drug and comes under BCS class-II by using solid dispersion technique. Lamotrigine, PEG 4000 and PVPK-30 solid dispersion was prepared by solvent evaporation method and the formulation was...