Breast cancer is one the most important health concerns of the modern society (Ferlay et al., 2007). Worldwide, it is estimated that over one million new cases of breast cancer are diagnosed every year, and more than 400 thousands will die from the breast cancer (Coughlin & Ekwueme, 2009) The life-time risk in women contracting breast cancers is estimated to be 1 in 8, which is the highest amon...

Chronic wounds and severe burns are diseases responsible for severe morbidity and even death. Wound repair is a crucial process and tissue regeneration enhancement and infection prevention are key factors to minimize pain, discomfort, and scar formation. The aim of this work was the development of lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers [NLC]), to be loa...

BACKGROUND The present study takes advantage of the beneficial effects of resveratrol as a neuroprotective compound. Resveratrol-loaded solid lipid nanoparticles were functionalized with apolipoprotein E which can be recognized by the LDL receptors overexpressed on the blood-brain barrier. RESULTS Transmission electron microscopy images revealed spherical nanoparticles, dynamic light scatteri...

Lipid nanoparticles of the cancer drug Chlorambucil (CLB) were prepared by ultrasonication, using stearic acid as the core lipid. Four types of lipid nanoparticle formulations were studied: (i) stearic acid solid lipid nanoparticles (SLN); (ii) sterically stabilized SLN with pegylated phospholipids as stabilizer; (iii) nanostructured lipid complexes with oleic acid as adjunct lipid; (iv) lipid ...

The enhancement in cancer chemotherapy through incorporation into solid lipid nanoparticles (SLN) drug delivery system carries a lot of potential. Improving tumor diffusivity, improvement of body distribution, enhancing cellular uptake and inhibiting multidrug resistance mechanism are the main attributes. The availability of variety of methods of preparation with scale up possibility and the hi...

INTRODUCTION Resveratrol is a polyphenol found in grapes and red wines. Interest in this polyphenol has increased due to its pharmacological cardio- and neuroprotective, chemopreventive, and antiaging effects, among others. Nevertheless, its pharmacokinetic properties are less favorable, since the compound has poor bioavailability, low water solubility, and is chemically unstable. To overcome t...

Nowadays, nanotechnology is used as a way to increase bioavailability and decrease the side effects of drugs nutrients. Micronutrients nutraceuticals such vitamins, carotenoids, polyunsaturated fatty acids polyphenols are classes food ingredients that essential for human health well-being. These compounds rarely added purely targeted application but rather in encapsulated, solid, dry product fo...