OBJECTIVES The aim of this study was to develop a novel method for automated quantification of cell-free hemoglobin (fHb) based on the HI (Roche Diagnostics). METHODS The novel fHb method based on the HI was correlated with fHb measured using the triple wavelength methods of both Harboe [fHb, g/L = (0.915 * HI + 2.634)/100] and Fairbanks et al. [fHb, g/L = (0.917 * HI + 2.131)/100]. fHb conce...

In vitro diagnostics (IVD) has huge potential. Primary drivers in the global market are the patient's awareness of infectious diseases, the introduction of advanced molecular and tissue diagnostic tests for patient-stratified and targeted anti-cancer therapy and, last but not least, the growing geriatric population. Rapid progress in device miniaturization and information technology (IT) offers...

Two models of capillary blood prothrombin time (PT) monitoring systems were evaluated for analytical performance and then compared with two routine PT systems using the reference manual technique and a high-sensitivity thromboplastin. Two sets of 60 and 80 plasmas were analyzed from anticoagulated patients stabilized over 3 months in an INR range 2-3.5 for therapy. Capillary PT determination wa...

Substantial investment has been made into the once "neglected" tropical disease, soil-transmitted helminthiasis, and into control programs that operate within a framework of mapping baseline disease distribution, measuring the effectiveness of applied interventions, establishing when to cease drug administration, and for posttreatment evaluations. However, critical to each of these stages is th...

Three pedons were selected representing the soil series of study area in Baiji city, which are Khadraniya, Al-Sharqat, and Manjour soils series, calcareous gypsiferous soils, to diagnose some micro-morphological Features horizons. Pedons morphologically described, disturbed undisturbed samples collected from each horizon. The presence (calcic) (gypsic) horizons has been diagnostic by morphologi...

This paper demonstrates the advantages of using on-line arithmetic for traditional and advanced detection algorithms for communication systems. Detection is one of the core computationallyintensive physical layer operations in a communication receiver and determines the communication data rates. Detection algorithms typically involve hard decisions (sign based testing) to find the sign of the t...

Measurement of lactate levels is important in the care of critically ill adult and pediatric patients. We compared 3 whole blood lactate methods (Radiometer ABL 725, Radiometer Medical A/S, Bronshoj, Denmark; i-STAT, i-STAT, East Windsor, NJ; and Nova Lactate Plus, Nova Biomedical, Waltham, MA) with 2 plasma-based methods (Roche Integra, Roche Diagnostics, Indianapolis, IN; and Vitros, Ortho Cl...

The discovery of diverse driver mutations in lung cancer has heralded a new era of personalized medicine in thoracic oncology, with targeted therapies approved for specific subgroups of patients. The increasing number of patient subgroups that may respond to targeted therapy has resulted in a greater reliance upon effective and increasingly complex diagnostics, which must be interpreted in an i...

Two unrelated patients underwent coronary angiography and a percutaneous intervention. At the end of the procedures, blood was collected (Vacutainer® SSTTM; BD) for troponin, creatine kinase (CK), and CK-MB isoenzyme analysis. After centrifugation with the Roche Modular Pre-Analytics system (Roche Diagnostics), pipetting error alerts were triggered on the aliquoting module of the Pre-Analytics ...